| Gene Information | |
|---|---|
| Gene Name | SLU7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 586 |
| Protein Names | Pre-mRNA-splicing factor SLU7 (hSlu7) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000164609 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O95391 |
| Gene Card | SLU7 |
| Uniprot ID | O95391 |
| Pfam | PF11708 |
| In ASD | no |
| Allosteric Prediction | no (-1.031909773) |
| Ortholog in Animals | Alpaca_ SLU7 ( ortholog_one2one ) Dog_ SLU7 ( ortholog_one2one ) GuineaPig_ SLU7 ( ortholog_one2one ) Macaque_ SLU7 ( ortholog_one2one ) Mouse_ Slu7 ( ortholog_one2one ) Pig_ SLU7 ( ortholog_one2one ) Rat_ Slu7 ( ortholog_one2one ) Rabbit_ SLU7 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.028121(Rat);0.146182(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5XJC (EM 3.60A ) 6ICZ (EM 3.00A ) 6QDV (EM 3.30A ) 7W5A (EM 3.60A ) 7W5B (EM 4.30A ) |
| DBSNP | rs17856338 rs2961944 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10197984, ECO:0000269|PubMed:15728250, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:30705154}. Nucleus speckle {ECO:0000269|PubMed:15181151}. Cytoplasm {ECO:0000269|PubMed:15728250}. Note=Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Upon UV-C stress stimulus, the nuclear concentration of the protein decreases, affecting alternative splicing. Translocates from the nucleus to the cytoplasm after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules. {ECO:0000269|PubMed:15728250}. |
| Mouse PG classification | NA |
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