| Gene Information | |
|---|---|
| Gene Name | CSK |
| Organism | Homo sapiens (Human) |
| Gene Length | 450 |
| Protein Names | Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL) |
| Target Name | tyrosine-protein kinase csk |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000103653 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P41240 |
| Gene Card | CSK |
| Uniprot ID | P41240 |
| Pfam | PF07714; PF00017; PF00018 |
| In ASD | yes |
| Allosteric Prediction | yes (1.751441973) |
| Ortholog in Animals | Alpaca_ CSK ( ortholog_one2one ) Dog_ CSK ( ortholog_one2one ) GuineaPig_ CSK ( ortholog_one2one ) Macaque_ CSK ( ortholog_one2one ) Mouse_ Csk ( ortholog_one2one ) Pig_ CSK ( ortholog_one2one ) Rat_ Csk ( ortholog_one2one ) |
| Ohnologs | MATK |
| Paralogs | FGR, FRK, JAK3, BMX, FER, BTK, FES, BLK, JAK1, PTK2B, SYK, TYK2, LYN, ZAP70, TXK, TNK2, PTK2, SRMS, TEC, STYK1, YES1, LCK, SRC, JAK2, ITK, MATK, TNK1, HCK, ABL1, ABL2, FYN, PTK6 |
| Tissue | NA |
| Tissue Specificity | Expressed in lung and macrophages. {ECO:0000269|PubMed:1371489}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001360(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1BYG (X-ray 2.40A ) 1CSK (X-ray 2.50A ) 3D7T (X-ray 2.90A ) 3D7U (X-ray 4.11A ) 3EAC (X-ray 1.37A ) 3EAZ (X-ray 1.31A ) |
| DBSNP | rs34866753 rs34616395 rs35556162 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Mainly cytoplasmic, also present in lipid rafts. {ECO:0000250}. |
| Mouse PG classification | NA |
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