| Gene Information | |
|---|---|
| Gene Name | CSF2RB |
| Organism | Homo sapiens (Human) |
| Gene Length | 897 |
| Protein Names | Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131) |
| Target Name | interleukin 3 receptor |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000100368 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P32927 |
| Gene Card | CSF2RB |
| Uniprot ID | P32927 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | yes (0.177114309) |
| Ortholog in Animals | Alpaca_ CSF2RB ( ortholog_one2one ) Dog_ CSF2RB ( ortholog_one2one ) GuineaPig_ CSF2RB ( ortholog_one2one ) Macaque_ CSF2RB ( ortholog_one2one ) Mouse_ Csf2rb2 ( ortholog_one2many ) Mouse_ Csf2rb ( ortholog_one2many ) Pig_ CSF2RB ( ortholog_one2one ) Rat_ Csf2rb ( ortholog_one2one ) Rabbit_ CSF2RB ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MPL, IL4R, IL2RB, IL7R, IL9R, IL21R, EPOR |
| Tissue | lung, spleen, whole.blood |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003657(Rat);0.071429(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1C8P (NMR - ) 1EGJ (X-ray 2.80A ) 1GH7 (X-ray 3.00A ) 2GYS (X-ray 2.70A ) 2NA8 (NMR - ) 2NA9 (NMR - ) 4NKQ (X-ray 3.30A ) 5DWU (X-ray 3.97A ) |
| DBSNP | rs16845 rs1801122 rs1801115 rs1801114 rs16997517 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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