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Gene Information
Gene Name
CSBP
Organism
Homo sapiens (Human)
Gene Length
360
Protein Names
Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a)
Target Name
NA
Target Type
NA
Gene Age
NA
Evolutionary Stage
NA
AlphaFoldDB
Q16539
Gene Card
MAPK14
Uniprot ID
Q16539
Pfam
PF00069
In ASD
yes
Allosteric Prediction
NA
Ortholog in Animals
NA
Ohnologs
NA
Paralogs
NA
Tissue
NA
Tissue Specificity
Brain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung, liver and kidney.
Pharmacological Animal Models
NULL(Chimpanzee);NULL(Mouse);0.001844(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
1A9U
(X-ray
2.50A
)
1BL6
(X-ray
2.50A
)
1BL7
(X-ray
2.50A
)
1BMK
(X-ray
2.40A
)
1DI9
(X-ray
2.60A
)
1IAN
(X-ray
2.00A
)
1KV1
(X-ray
2.50A
)
1KV2
(X-ray
2.80A
)
1M7Q
(X-ray
2.40A
)
1OUK
(X-ray
2.50A
)
1OUY
(X-ray
2.50A
)
1OVE
(X-ray
2.10A
)
1OZ1
(X-ray
2.10A
)
1R39
(X-ray
2.30A
)
1R3C
(X-ray
2.00A
)
1W7H
(X-ray
2.21A
)
1W82
(X-ray
2.20A
)
1W83
(X-ray
2.50A
)
1W84
(X-ray
2.20A
)
1WBN
(X-ray
2.40A
)
1WBO
(X-ray
2.16A
)
1WBS
(X-ray
1.80A
)
1WBT
(X-ray
2.00A
)
1WBV
(X-ray
2.00A
)
1WBW
(X-ray
2.41A
)
1WFC
(X-ray
2.30A
)
1YQJ
(X-ray
2.00A
)
1ZYJ
(X-ray
2.00A
)
1ZZ2
(X-ray
2.00A
)
1ZZL
(X-ray
2.00A
)
2BAJ
(X-ray
2.25A
)
2BAK
(X-ray
2.20A
)
2BAL
(X-ray
2.10A
)
2BAQ
(X-ray
2.80A
)
2FSL
(X-ray
1.70A
)
2FSM
(X-ray
1.86A
)
2FSO
(X-ray
1.83A
)
2FST
(X-ray
1.45A
)
2GFS
(X-ray
1.75A
)
2I0H
(X-ray
2.00A
)
2LGC
(NMR
-
)
2NPQ
(X-ray
1.80A
)
2OKR
(X-ray
2.00A
)
2ONL
(X-ray
4.00A
)
2QD9
(X-ray
1.70A
)
2RG5
(X-ray
2.40A
)
2RG6
(X-ray
1.72A
)
2Y8O
(X-ray
1.95A
)
2YIS
(X-ray
2.00A
)
2YIW
(X-ray
2.00A
)
2YIX
(X-ray
2.30A
)
2ZAZ
(X-ray
1.80A
)
2ZB0
(X-ray
2.10A
)
2ZB1
(X-ray
2.50A
)
3BV2
(X-ray
2.40A
)
3BV3
(X-ray
2.59A
)
3BX5
(X-ray
2.40A
)
3C5U
(X-ray
2.80A
)
3CTQ
(X-ray
1.95A
)
3D7Z
(X-ray
2.10A
)
3D83
(X-ray
1.90A
)
3DS6
(X-ray
2.90A
)
3DT1
(X-ray
2.80A
)
3E92
(X-ray
2.00A
)
3E93
(X-ray
2.00A
)
3FC1
(X-ray
2.40A
)
3FI4
(X-ray
2.20A
)
3FKL
(X-ray
2.00A
)
3FKN
(X-ray
2.00A
)
3FKO
(X-ray
2.00A
)
3FL4
(X-ray
1.80A
)
3FLN
(X-ray
1.90A
)
3FLQ
(X-ray
1.90A
)
3FLS
(X-ray
2.30A
)
3FLW
(X-ray
2.10A
)
3FLY
(X-ray
1.80A
)
3FLZ
(X-ray
2.23A
)
3FMH
(X-ray
1.90A
)
3FMJ
(X-ray
2.00A
)
3FMK
(X-ray
1.70A
)
3FML
(X-ray
2.10A
)
3FMM
(X-ray
2.00A
)
3FMN
(X-ray
1.90A
)
3FSF
(X-ray
2.10A
)
3FSK
(X-ray
2.00A
)
3GC7
(X-ray
1.80A
)
3GCP
(X-ray
2.25A
)
3GCQ
(X-ray
2.00A
)
3GCS
(X-ray
2.10A
)
3GCU
(X-ray
2.10A
)
3GCV
(X-ray
2.30A
)
3GFE
(X-ray
2.10A
)
3GI3
(X-ray
2.40A
)
3HA8
(X-ray
2.48A
)
3HEC
(X-ray
2.50A
)
3HEG
(X-ray
2.20A
)
3HL7
(X-ray
1.88A
)
3HLL
(X-ray
1.95A
)
3HP2
(X-ray
2.15A
)
3HP5
(X-ray
2.30A
)
3HRB
(X-ray
2.20A
)
3HUB
(X-ray
2.25A
)
3HUC
(X-ray
1.80A
)
3HV3
(X-ray
2.00A
)
3HV4
(X-ray
2.60A
)
3HV5
(X-ray
2.25A
)
3HV6
(X-ray
1.95A
)
3HV7
(X-ray
2.40A
)
3HVC
(X-ray
2.10A
)
3IPH
(X-ray
2.10A
)
3ITZ
(X-ray
2.25A
)
3IW5
(X-ray
2.50A
)
3IW6
(X-ray
2.10A
)
3IW7
(X-ray
2.40A
)
3IW8
(X-ray
2.00A
)
3K3I
(X-ray
1.70A
)
3K3J
(X-ray
2.00A
)
3KF7
(X-ray
2.00A
)
3KQ7
(X-ray
1.80A
)
3L8S
(X-ray
2.35A
)
3L8X
(X-ray
2.15A
)
3LFA
(X-ray
2.10A
)
3LFB
(X-ray
2.60A
)
3LFC
(X-ray
2.80A
)
3LFD
(X-ray
3.40A
)
3LFE
(X-ray
2.30A
)
3LFF
(X-ray
1.50A
)
3LHJ
(X-ray
3.31A
)
3MGY
(X-ray
2.10A
)
3MH0
(X-ray
2.00A
)
3MH1
(X-ray
2.20A
)
3MH2
(X-ray
2.30A
)
3MH3
(X-ray
2.20A
)
3MPA
(X-ray
2.10A
)
3MPT
(X-ray
1.89A
)
3MVL
(X-ray
2.80A
)
3MVM
(X-ray
2.00A
)
3MW1
(X-ray
2.80A
)
3NEW
(X-ray
2.51A
)
3NNU
(X-ray
2.40A
)
3NNV
(X-ray
2.10A
)
3NNW
(X-ray
1.89A
)
3NNX
(X-ray
2.28A
)
3NWW
(X-ray
2.09A
)
3O8P
(X-ray
2.10A
)
3O8T
(X-ray
2.00A
)
3O8U
(X-ray
2.10A
)
3OBG
(X-ray
2.80A
)
3OBJ
(X-ray
2.40A
)
3OC1
(X-ray
2.59A
)
3OCG
(X-ray
2.21A
)
3OD6
(X-ray
2.68A
)
3ODY
(X-ray
2.20A
)
3ODZ
(X-ray
2.30A
)
3OEF
(X-ray
1.60A
)
3PG3
(X-ray
2.00A
)
3QUD
(X-ray
2.00A
)
3QUE
(X-ray
2.70A
)
3RIN
(X-ray
2.20A
)
3ROC
(X-ray
1.70A
)
3S3I
(X-ray
1.80A
)
3S4Q
(X-ray
2.27A
)
3U8W
(X-ray
2.15A
)
3UVP
(X-ray
2.40A
)
3UVQ
(X-ray
2.20A
)
3UVR
(X-ray
2.10A
)
3ZS5
(X-ray
1.60A
)
3ZSG
(X-ray
1.89A
)
3ZSH
(X-ray
2.05A
)
3ZSI
(X-ray
2.40A
)
3ZYA
(X-ray
1.90A
)
4A9Y
(X-ray
2.20A
)
4AA0
(X-ray
1.80A
)
4AA4
(X-ray
2.30A
)
4AA5
(X-ray
2.38A
)
4AAC
(X-ray
2.50A
)
4DLI
(X-ray
1.91A
)
4DLJ
(X-ray
2.60A
)
4E5A
(X-ray
1.87A
)
4E5B
(X-ray
2.00A
)
4E6A
(X-ray
2.09A
)
4E6C
(X-ray
2.39A
)
4E8A
(X-ray
2.70A
)
4EH2
(X-ray
2.00A
)
4EH3
(X-ray
2.40A
)
4EH4
(X-ray
2.50A
)
4EH5
(X-ray
2.00A
)
4EH6
(X-ray
2.10A
)
4EH7
(X-ray
2.10A
)
4EH8
(X-ray
2.20A
)
4EH9
(X-ray
2.10A
)
4EHV
(X-ray
1.60A
)
4EWQ
(X-ray
2.10A
)
4F9W
(X-ray
2.00A
)
4F9Y
(X-ray
1.85A
)
4FA2
(X-ray
2.00A
)
4GEO
(X-ray
1.66A
)
4KIN
(X-ray
1.97A
)
4KIP
(X-ray
2.27A
)
4KIQ
(X-ray
2.50A
)
4L8M
(X-ray
2.10A
)
4R3C
(X-ray
2.06A
)
4ZTH
(X-ray
2.15A
)
5ETA
(X-ray
2.80A
)
5ETC
(X-ray
2.42A
)
5ETF
(X-ray
2.40A
)
5ETI
(X-ray
2.80A
)
5ML5
(X-ray
1.90A
)
5MTX
(X-ray
1.80A
)
5MTY
(X-ray
2.31A
)
5MZ3
(X-ray
2.15A
)
5N63
(X-ray
2.40A
)
5N64
(X-ray
2.40A
)
5N65
(X-ray
2.00A
)
5N66
(X-ray
2.40A
)
5N67
(X-ray
1.90A
)
5N68
(X-ray
1.85A
)
5O8U
(X-ray
2.00A
)
5O8V
(X-ray
2.00A
)
5OMG
(X-ray
2.00A
)
5OMH
(X-ray
2.50A
)
5TBE
(X-ray
2.44A
)
5TCO
(X-ray
2.10A
)
5WJJ
(X-ray
1.60A
)
5XYX
(X-ray
2.61A
)
5XYY
(X-ray
1.70A
)
6ANL
(X-ray
2.00A
)
6HWT
(X-ray
1.70A
)
6HWU
(X-ray
2.30A
)
6HWV
(X-ray
1.70A
)
6M95
(X-ray
1.80A
)
6M9L
(X-ray
2.45A
)
6OHD
(X-ray
2.50A
)
6QDZ
(X-ray
1.73A
)
6QE1
(X-ray
1.85A
)
6QYX
(X-ray
1.66A
)
6RFO
(X-ray
1.70A
)
6SFI
(X-ray
1.60A
)
6SFJ
(X-ray
1.95A
)
6SFK
(X-ray
1.80A
)
6SFO
(X-ray
1.75A
)
6TCA
(X-ray
3.70A
)
6ZQS
(X-ray
1.95A
)
6ZWP
(X-ray
1.90A
)
8A8M
(EM
4.00A
)
DBSNP
rs45496794
Subcellular location [CC]
Cytoplasm {ECO:0000269|PubMed:7535770}. Nucleus {ECO:0000269|PubMed:30878395, ECO:0000269|PubMed:7535770}.
Mouse PG classification
NA
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