| Gene Information | |
|---|---|
| Gene Name | CHP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 195 |
| Protein Names | Calcineurin B homologous protein 1 (Calcineurin B-like protein) (Calcium-binding protein CHP) (Calcium-binding protein p22) (EF-hand calcium-binding domain-containing protein p22) |
| Target Name | calcineurin b homologous protein 1 |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000187446 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q99653 |
| Gene Card | CHP1 |
| Uniprot ID | Q99653 |
| Pfam | PF13499 |
| In ASD | no |
| Allosteric Prediction | no (-0.281715452) |
| Ortholog in Animals | Alpaca_ CHP1 ( ortholog_one2one ) Dog_ CHP1 ( ortholog_one2one ) GuineaPig_ CHP1 ( ortholog_one2one ) Macaque_ CHP1 ( ortholog_one2one ) Mouse_ Chp1 ( ortholog_one2one ) Pig_ CHP1 ( ortholog_one2one ) Rat_ Chp1 ( ortholog_one2many ) Rat_ AABR07048280.1 ( ortholog_one2many ) Rabbit_ CHP1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CIB1, CIB4, CIB3, TESC, PPP3R1, CIB2, CHP2, PPP3R2 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. Has been found in fetal eye, lung, liver, muscle, heart, kidney, thymus and spleen. {ECO:0000269|PubMed:8901634}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.005990(Rat);0.050000(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2E30 (NMR - ) 7DSV (EM 3.40A ) 7DSX (EM 3.50A ) 7X2U (EM 3.20A ) |
| DBSNP | rs1310569366 |
| Subcellular location [CC] | Nucleus {ECO:0000250|UniProtKB:P61023}. Cytoplasm {ECO:0000250|UniProtKB:P61023}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P61023}. Endomembrane system {ECO:0000250|UniProtKB:P61023}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250|UniProtKB:P61023}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P61023}. Cell membrane {ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:29379881}. Membrane {ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:29379881}; Lipid-anchor {ECO:0000269|PubMed:25255805}. Note=Localizes in cytoplasmic compartments in dividing cells. Localizes in the nucleus in quiescent cells. Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) and CRM1-dependent pathway. May shuttle between nucleus and cytoplasm. Localizes with the microtubule-organizing center (MTOC) and extends toward the periphery along microtubules. Associates with membranes of the early secretory pathway in a GAPDH-independent, N-myristoylation- and calcium-dependent manner. Colocalizes with the mitotic spindle microtubules. Colocalizes with GAPDH along microtubules. Colocalizes with SLC9A1 at the reticulum endoplasmic and plasma membrane. Colocalizes with STK17B at the plasma membrane. {ECO:0000250|UniProtKB:P61023}. |
| Mouse PG classification | NA |
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