| Gene Information | |
|---|---|
| Gene Name | CBLL2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 425 |
| Protein Names | E3 ubiquitin-protein ligase CBLL2 (EC 2.3.2.27) (Cbl proto-oncogene-like protein 2) (RING-type E3 ubiquitin transferase ZNF645) (Zinc finger protein 645) (c-Cbl-like protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 25 ( ENSG00000175809 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8N7E2 |
| Gene Card | CBLL2 |
| Uniprot ID | Q8N7E2 |
| Pfam | PF18408 |
| In ASD | no |
| Allosteric Prediction | no (-0.716023803) |
| Ortholog in Animals | Alpaca_ CBLL2 ( ortholog_one2one ) Dog_ CBLL1 ( ortholog_one2one ) Macaque_ CBLL2 ( ortholog_one2one ) |
| Ohnologs | CBLL1 |
| Paralogs | CBLL1 |
| Tissue | NA |
| Tissue Specificity | Exclusively expressed in testis and sperm, including spermatocytes, round and elongated spermatids, and Leydig cells. {ECO:0000269|PubMed:20657603}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs5951426 rs12860105 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:20657603}. Note=Localized over the postacrosomal perinuclear theca region and the entire length of sperm tail. {ECO:0000269|PubMed:20657603}. |
| Mouse PG classification | NA |
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