| Gene Information | |
|---|---|
| Gene Name | CRYAA |
| Organism | Homo sapiens (Human) |
| Gene Length | 173 |
| Protein Names | Alpha-crystallin A chain (Heat shock protein beta-4) (HspB4) [Cleaved into: Alpha-crystallin A(1-172); Alpha-crystallin A(1-168); Alpha-crystallin A(1-162)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000160202 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P02489 |
| Gene Card | CRYAA |
| Uniprot ID | P02489 |
| Pfam | PF00525; PF00011 |
| In ASD | no |
| Allosteric Prediction | no (-0.932513713) |
| Ortholog in Animals | Alpaca_ CRYAA ( ortholog_one2one ) Dog_ CRYAA ( ortholog_one2one ) GuineaPig_ Cryaa ( ortholog_one2one ) Macaque_ CRYAA ( ortholog_one2one ) Mouse_ Cryaa ( ortholog_one2one ) Pig_ CRYAA ( ortholog_one2one ) Rabbit_ CRYAA ( ortholog_one2one ) |
| Ohnologs | HSPB6, CRYAB, HSPB2 |
| Paralogs | CRYAB, HSPB3, HSPB6, HSPB1, HSPB2, HSPB8, HSPB7, HSPB9 |
| Tissue | kidney |
| Tissue Specificity | Expressed in the eye lens (at protein level). {ECO:0000269|PubMed:12356833, ECO:0000269|PubMed:23255486}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.06(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6T1R (EM 9.80A ) |
| DBSNP | rs74315440 rs397515624 rs397515626 rs397515625 rs74315441 rs397515623 rs199640007 rs398122947 rs74315439 rs121912973 rs367826363 rs760170206 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:14512969, ECO:0000269|PubMed:19464326, ECO:0000269|PubMed:19503744, ECO:0000269|PubMed:26004348, ECO:0000269|PubMed:30340470}. Nucleus {ECO:0000269|PubMed:19464326}. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. |
| Mouse PG classification | NA |
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