| Gene Information | |
|---|---|
| Gene Name | CRY2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 593 |
| Protein Names | Cryptochrome-2 |
| Target Name | cryptochrome-2 |
| Target Type | Preclinical target |
| Gene Age | 544 ( ENSG00000121671 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q49AN0 |
| Gene Card | CRY2 |
| Uniprot ID | Q49AN0 |
| Pfam | PF00875; PF03441 |
| In ASD | no |
| Allosteric Prediction | yes (0.068868543) |
| Ortholog in Animals | Alpaca_ CRY2 ( ortholog_one2one ) Dog_ CRY2 ( ortholog_one2one ) GuineaPig_ CRY2 ( ortholog_one2one ) Macaque_ CRY2 ( ortholog_one2one ) Mouse_ Cry2 ( ortholog_one2one ) Pig_ CRY2 ( ortholog_one2one ) Rat_ Cry2 ( ortholog_one2one ) Rabbit_ CRY2 ( ortholog_one2one ) |
| Ohnologs | CRY1 |
| Paralogs | CRY1 |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues examined including fetal brain, fibroblasts, heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Highest levels in heart and skeletal muscle. {ECO:0000269|PubMed:8909283, ECO:0000269|PubMed:9801304}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:9801304}. Nucleus {ECO:0000269|PubMed:22798407, ECO:0000269|PubMed:9801304}. Note=Translocated to the nucleus through interaction with other Clock proteins such as PER2 or BMAL1. |
| Mouse PG classification | NA |
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