| Gene Information | |
|---|---|
| Gene Name | CRTC2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 693 |
| Protein Names | CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000160741 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q53ET0 |
| Gene Card | CRTC2 |
| Uniprot ID | Q53ET0 |
| Pfam | PF12886; PF12885; PF12884 |
| In ASD | no |
| Allosteric Prediction | yes (0.080075609) |
| Ortholog in Animals | Alpaca_ CRTC2 ( ortholog_one2one ) Dog_ CRTC2 ( ortholog_one2one ) GuineaPig_ CRTC2 ( ortholog_one2one ) Macaque_ CRTC2 ( ortholog_one2one ) Mouse_ Crtc2 ( ortholog_one2one ) Pig_ CRTC2 ( ortholog_one2one ) Rat_ Crtc2 ( ortholog_one2one ) Rabbit_ CRTC2 ( ortholog_one2one ) |
| Ohnologs | CRTC1, CRTC3 |
| Paralogs | CRTC1, CRTC3 |
| Tissue | NA |
| Tissue Specificity | Most abundantly expressed in the thymus. Present in both B and T-lymphocytes. Highly expressed in HEK293T cells and in insulinomas. High levels also in spleen, ovary, muscle and lung, with highest levels in muscle. Lower levels found in brain, colon, heart, kidney, prostate, small intestine and stomach. Weak expression in liver and pancreas. {ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16980408}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.036364(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4HTM (X-ray 2.00A ) |
| DBSNP | rs11264680 rs150423770 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15589160}. Nucleus {ECO:0000269|PubMed:15589160}. Note=Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein (PubMed:15454081). In response to cAMP levels and glucagon, relocated to the nucleus (PubMed:15454081). {ECO:0000269|PubMed:15454081}. |
| Mouse PG classification | NA |
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