| Gene Information | |
|---|---|
| Gene Name | PRSS10 |
| Organism | Homo sapiens (Human) |
| Gene Length | 492 |
| Protein Names | Transmembrane protease serine 2 (EC 3.4.21.-) (Serine protease 10) [Cleaved into: Transmembrane protease serine 2 non-catalytic chain; Transmembrane protease serine 2 catalytic chain] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O15393 |
| Gene Card | TMPRSS2 |
| Uniprot ID | O15393 |
| Pfam | PF15494; PF00089 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in several tissues that comprise large populations of epithelial cells with the highest level of transcripts measured in the prostate gland. Expressed in type II pneumocytes in the lung (at protein level). Expressed strongly in small intestine. Also expressed in colon, stomach and salivary gland. Coexpressed with ACE2 within lung type II pneumocytes, ileal absorptive enterocytes, intestinal epithelial cells, cornea, gallbladder and nasal goblet secretory cells (Ref.21). {ECO:0000269|PubMed:11169526, ECO:0000269|PubMed:20382709, ECO:0000269|PubMed:21325420, ECO:0000269|PubMed:32404436, ECO:0000269|Ref.21}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);0.002240(Rat);0.111111(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 7MEQ (X-ray 1.95A ) |
| DBSNP | rs12329760 rs775137340 rs1056602 rs779875214 rs200291871 rs75603675 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:20382709, ECO:0000269|PubMed:21068237}; Single-pass type II membrane protein {ECO:0000269|PubMed:20382709, ECO:0000269|PubMed:21068237}.; [Transmembrane protease serine 2 catalytic chain]: Secreted {ECO:0000269|PubMed:20382709}. Note=Activated by cleavage and secreted. {ECO:0000269|PubMed:11245484, ECO:0000269|PubMed:20382709}. |
| Mouse PG classification | NA |
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