| Gene Information | |
|---|---|
| Gene Name | CHMP1A |
| Organism | Homo sapiens (Human) |
| Gene Length | 196 |
| Protein Names | Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a) (Vacuolar protein sorting-associated protein 46-1) (Vps46-1) (hVps46-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000131165 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9HD42 |
| Gene Card | CHMP1A |
| Uniprot ID | Q9HD42 |
| Pfam | PF03357 |
| In ASD | no |
| Allosteric Prediction | no (-1.188794254) |
| Ortholog in Animals | Dog_ CHMP1A ( ortholog_one2one ) GuineaPig_ CHMP1A ( ortholog_one2one ) Mouse_ Chmp1a ( ortholog_one2one ) Pig_ CHMP1A ( ortholog_one2one ) Rat_ Chmp1a ( ortholog_one2one ) Rabbit_ CHMP1A ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CHMP1B, CHMP2B, CHMP3, CHMP2A |
| Tissue | NA |
| Tissue Specificity | Expressed in placenta, cultured skin fibroblasts and in osteoblast cell line MG-63. {ECO:0000269|PubMed:8863740}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.213858(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2JQ9 (NMR - ) 2YMB (X-ray 3.40A ) 4A5X (X-ray 1.91A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm. Endosome membrane; Peripheral membrane protein. Nucleus matrix. Note=The cytoplasmic form is partially membrane-associated and localizes to early endosomes. The nuclear form remains associated with the chromosome scaffold during mitosis. On overexpression, it localizes to nuclear bodies characterized by nuclease-resistant condensed chromatin. |
| Mouse PG classification | NA |
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