| Gene Information | |
|---|---|
| Gene Name | CROCC |
| Organism | Homo sapiens (Human) |
| Gene Length | 2017 |
| Protein Names | Rootletin (Ciliary rootlet coiled-coil protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000058453 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q5TZA2 |
| Gene Card | CROCC |
| Uniprot ID | Q5TZA2 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.129209771) |
| Ortholog in Animals | Alpaca_ CROCC ( ortholog_one2one ) Dog_ CROCC ( ortholog_one2one ) GuineaPig_ CROCC ( ortholog_one2one ) Macaque_ CROCC ( ortholog_one2one ) Mouse_ Crocc ( ortholog_one2one ) Pig_ CROCC ( ortholog_one2one ) Rat_ Crocc ( ortholog_one2one ) |
| Ohnologs | CEP250 |
| Paralogs | CEP135, CROCC2, TSGA10, CEP250 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6L5H (X-ray 1.30A ) 6L5J (X-ray 2.77A ) |
| DBSNP | rs6586566 rs57442576 rs4463721 rs9435714 rs6669627 rs749003874 rs374780265 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:14654843}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:27623382}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:27623382, ECO:0000269|PubMed:31974111}. Note=In ciliated cells, associated with ciliary rootlets. In non-ciliated cells, localized between, around and at the proximal ends of the centrioles. Dissociates from the centrioles at the onset of mitosis and reassociates with them at anaphase. {ECO:0000269|PubMed:14654843}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |