| Gene Information | |
|---|---|
| Gene Name | FES |
| Organism | Homo sapiens (Human) |
| Gene Length | 822 |
| Protein Names | Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes) |
| Target Name | tyrosine-protein kinase fes/fps |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000182511 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P07332 |
| Gene Card | FES |
| Uniprot ID | P07332 |
| Pfam | PF07714; PF00017 |
| In ASD | no |
| Allosteric Prediction | yes (0.323502604) |
| Ortholog in Animals | Alpaca_ FES ( ortholog_one2one ) Dog_ FES ( ortholog_one2one ) Macaque_ FES ( ortholog_one2one ) Mouse_ Fes ( ortholog_one2one ) Pig_ FES ( ortholog_one2one ) Rat_ Fes ( ortholog_one2one ) Rabbit_ FES ( ortholog_one2one ) |
| Ohnologs | FER |
| Paralogs | FGR, FRK, JAK3, BMX, FER, BTK, BLK, JAK1, PTK2B, SYK, TYK2, LYN, ZAP70, TXK, TNK2, PTK2, SRMS, TEC, CSK, STYK1, YES1, LCK, SRC, JAK2, ITK, MATK, TNK1, HCK, ABL1, ABL2, FYN, PTK6 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Detected in adult colon epithelium (at protein level) (PubMed:16455651, PubMed:19051325). Expressed in melanocytes (at protein level) (PubMed:28463229). {ECO:0000269|PubMed:16455651, ECO:0000269|PubMed:19051325, ECO:0000269|PubMed:28463229}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 1WQU (NMR - ) 2DCR (NMR - ) 3BKB (X-ray 1.78A ) 3CBL (X-ray 1.75A ) 3CD3 (X-ray 1.98A ) 4DYL (X-ray 2.18A ) 4E93 (X-ray 1.84A ) 6JMF (X-ray 2.00A ) 7T1K (X-ray 1.25A ) 7T1L (X-ray 1.35A ) |
| DBSNP | rs56041861 rs34573430 rs56296062 |
| Subcellular location [CC] | Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Golgi apparatus. Cell junction, focal adhesion. Note=Distributed throughout the cytosol when the kinase is not activated. Association with microtubules requires activation of the kinase activity. Shuttles between focal adhesions and cell-cell contacts in epithelial cells. Recruited to the lateral cell membrane in polarized epithelial cells by interaction with phosphorylated EZR. Detected at tubular membrane structures in the cytoplasm and at the cell periphery. |
| Mouse PG classification | NA |
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