| Gene Information | |
|---|---|
| Gene Name | CNNM2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 875 |
| Protein Names | Metal transporter CNNM2 (Ancient conserved domain-containing protein 2) (Cyclin-M2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000148842 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H8M5 |
| Gene Card | CNNM2 |
| Uniprot ID | Q9H8M5 |
| Pfam | PF00571; PF01595 |
| In ASD | no |
| Allosteric Prediction | no (-0.145185751) |
| Ortholog in Animals | Alpaca_ CNNM2 ( ortholog_one2one ) Dog_ CNNM2 ( ortholog_one2one ) GuineaPig_ CNNM2 ( ortholog_one2one ) Macaque_ CNNM2 ( ortholog_one2one ) Mouse_ Cnnm2 ( ortholog_one2one ) Pig_ CNNM2 ( ortholog_one2one ) Rat_ Cnnm2 ( ortholog_one2one ) Rabbit_ CNNM2 ( ortholog_one2one ) |
| Ohnologs | CNNM4, CNNM3 |
| Paralogs | CNNM4, CNNM3, CNNM1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Expressed at higher level in brain, kidney and placenta, while it is weakly expressed in skeletal muscle. In the kidney, it is expressed in the distal convoluted tubule and the thick ascending limb of Henle loop. {ECO:0000269|PubMed:21397062}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4IY0 (X-ray 1.90A ) 4IY2 (X-ray 3.60A ) 4IY4 (X-ray 2.90A ) 4IYS (X-ray 1.80A ) 6DJ3 (X-ray 2.60A ) 6N7E (X-ray 3.50A ) |
| DBSNP | rs76057237 rs786205909 rs794726858 rs786205910 rs387906975 |
| Subcellular location [CC] | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Mouse PG classification | NA |
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