| Gene Information | |
|---|---|
| Gene Name | SPINT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 529 |
| Protein Names | Kunitz-type protease inhibitor 1 (Hepatocyte growth factor activator inhibitor type 1) (HAI-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000166145 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O43278 |
| Gene Card | SPINT1 |
| Uniprot ID | O43278 |
| Pfam | PF00014; PF00057; PF07502 |
| In ASD | no |
| Allosteric Prediction | no (-0.305635795) |
| Ortholog in Animals | Alpaca_ SPINT1 ( ortholog_one2one ) Dog_ SPINT1 ( ortholog_one2one ) GuineaPig_ SPINT1 ( ortholog_one2one ) Macaque_ SPINT1 ( ortholog_one2one ) Mouse_ Spint1 ( ortholog_one2one ) Pig_ SPINT1 ( ortholog_one2one ) Rat_ Spint1 ( ortholog_one2one ) Rabbit_ SPINT1 ( ortholog_one2one ) |
| Ohnologs | SPINT2 |
| Paralogs | SPINT4, EPPIN, WFIKKN1, KIAA0319, TFPI, TFPI2, AMBP, SPINT2, WFIKKN2, WFDC8, LRP11, KIAA0319L, WFDC6 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003490(Rat);0.05(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1YC0 (X-ray 2.60A ) 2MSX (NMR - ) 4ISL (X-ray 2.29A ) 4ISN (X-ray 2.45A ) 4ISO (X-ray 2.01A ) 5EZD (X-ray 2.10A ) 5H7V (X-ray 3.82A ) |
| DBSNP | rs11549915 rs12323939 rs7165897 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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