| Gene Information | |
|---|---|
| Gene Name | KL |
| Organism | Homo sapiens (Human) |
| Gene Length | 1012 |
| Protein Names | Klotho (EC 3.2.1.31) [Cleaved into: Klotho peptide] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000133116 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9UEF7 |
| Gene Card | KL |
| Uniprot ID | Q9UEF7 |
| Pfam | PF00232 |
| In ASD | no |
| Allosteric Prediction | yes (0.582514932) |
| Ortholog in Animals | Alpaca_ KL ( ortholog_one2one ) Dog_ KL ( ortholog_one2one ) GuineaPig_ KL ( ortholog_one2one ) Macaque_ KL ( ortholog_one2one ) Mouse_ Kl ( ortholog_one2one ) Rat_ Kl ( ortholog_one2one ) Rabbit_ KL ( ortholog_one2one ) |
| Ohnologs | LCTL, KLB |
| Paralogs | LCT, GBA3, LCTL, KLB |
| Tissue | kidney |
| Tissue Specificity | Present in cortical renal tubules (at protein level). Soluble peptide is present in serum and cerebrospinal fluid. Expressed in kidney, placenta, small intestine and prostate. Down-regulated in renal cell carcinomas, hepatocellular carcinomas, and in chronic renal failure kidney. {ECO:0000269|PubMed:10631108, ECO:0000269|PubMed:11043382, ECO:0000269|PubMed:11162628, ECO:0000269|PubMed:15135068, ECO:0000269|PubMed:9464267}. |
| Pharmacological Animal Models | 0.127596(Chimpanzee);0.091155(Mouse);0.003490(Rat);0.050000(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5W21 (X-ray 3.00A ) |
| DBSNP | rs1052018 rs1052019 rs121908423 rs9536314 rs9527025 rs3752472 rs139939367 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane {ECO:0000269|PubMed:10631108, ECO:0000269|PubMed:15135068}; Single-pass type I membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000250|UniProtKB:O35082}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O35082}. Note=Isoform 1 shedding leads to a soluble peptide. {ECO:0000250|UniProtKB:O35082}.; [Isoform 2]: Secreted {ECO:0000269|PubMed:10631108, ECO:0000269|PubMed:15135068}.; [Klotho peptide]: Secreted {ECO:0000250|UniProtKB:O35082}. |
| Mouse PG classification | HPG |
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