| Gene Information | |
|---|---|
| Gene Name | GCNA |
| Organism | Homo sapiens (Human) |
| Gene Length | 691 |
| Protein Names | Germ cell nuclear acidic protein (Acidic repeat-containing protein) (Germ cell nuclear acidic peptidase) (Germ cell nuclear antigen) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000147174 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96QF7 |
| Gene Card | GCNA |
| Uniprot ID | Q96QF7 |
| Pfam | PF10263 |
| In ASD | no |
| Allosteric Prediction | no (-1.615512589) |
| Ortholog in Animals | Alpaca_ GCNA ( ortholog_one2one ) Macaque_ GCNA ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | adrenal.gland, testis |
| Tissue Specificity | Expressed in germ cells of the testis (at protein level) (PubMed:27718356). Detected in skeletal muscle, liver, kidney, pancreas, heart, lung and brain (PubMed:11714101). Expressed throughout spermatogenesis, from spermatogonia to elongated spermatids, in normal adult testis (at protein level) (PubMed:33963445). {ECO:0000269|PubMed:11714101, ECO:0000269|PubMed:27718356, ECO:0000269|PubMed:33963445}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs746349614 rs200457016 rs766534592 rs143368028 rs141229655 rs199853865 rs761086272 rs144602884 rs776093985 rs10217999 rs756204489 rs2280962 rs138927483 rs376298923 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:27718356, ECO:0000305|PubMed:11714101}. Nucleus, PML body {ECO:0000269|PubMed:30914427}. Chromosome {ECO:0000250|UniProtKB:A0A1D9BZF0}. Note=Co-localizes with SUMO2 at PML bodies in all interphase cells (PubMed:30914427). Localizes on condensed chromosomes in spermatocytes in G2 and M during meiotic prophase (By similarity). {ECO:0000250|UniProtKB:A0A1D9BZF0, ECO:0000269|PubMed:30914427}. |
| Mouse PG classification | NA |
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