Gene Information
Gene NameCREB4
OrganismHomo sapiens (Human)
Gene Length395
Protein NamesCyclic AMP-responsive element-binding protein 3-like protein 4 (cAMP-responsive element-binding protein 3-like protein 4) (Androgen-induced basic leucine zipper protein) (AIbZIP) (Attaching to CRE-like 1) (ATCE1) (Cyclic AMP-responsive element-binding protein 4) (CREB-4) (cAMP-responsive element-binding protein 4) (Transcript induced in spermiogenesis protein 40) (Tisp40) (hJAL) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 4]
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBQ8TEY5
Gene CardCREB3L4
Uniprot IDQ8TEY5
PfamPF00170
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityAccording to PubMed:11830526, exclusively expressed in the prostate. Expressed in breast and prostate cancer cell lines. Expressed in prostatic luminal epithelial cells (at protein level). Expression is significantly more abundant in prostate cancer than in benign prostatic tissue (prostatic hyperplasia). According to PubMed:12111373, also expressed in brain, pancreas and skeletal muscle, and at lower levels in small intestine, testis, leukocyte and thymus. {ECO:0000269|PubMed:11830526, ECO:0000269|PubMed:12111373, ECO:0000269|PubMed:17270658}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs11264743 
Subcellular location [CC]Endoplasmic reticulum membrane;
Single-pass type II membrane protein. Golgi apparatus membrane {ECO:0000305};
Single-pass type II membrane protein {ECO:0000305}. Note=May also be located in Golgi apparatus.;
[Processed cyclic AMP-responsive element-binding protein 3-like protein 4]: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. {ECO:0000250}.
Mouse PG classificationNA
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