| Gene Information | |
|---|---|
| Gene Name | CREB3L3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 461 |
| Protein Names | Cyclic AMP-responsive element-binding protein 3-like protein 3 (cAMP-responsive element-binding protein 3-like protein 3) (Transcription factor CREB-H) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 3] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000060566 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q68CJ9 |
| Gene Card | CREB3L3 |
| Uniprot ID | Q68CJ9 |
| Pfam | PF00170 |
| In ASD | no |
| Allosteric Prediction | no (-0.750448206) |
| Ortholog in Animals | Alpaca_ CREB3L3 ( ortholog_one2one ) Dog_ CREB3L3 ( ortholog_one2one ) GuineaPig_ CREB3L3 ( ortholog_one2one ) Macaque_ CREB3L3 ( ortholog_one2one ) Mouse_ Creb3l3 ( ortholog_one2one ) Pig_ CREB3L3 ( ortholog_one2one ) Rat_ Creb3l3 ( ortholog_one2one ) |
| Ohnologs | CREB3L4 |
| Paralogs | CREB3L2, ATF6, ATF1, ATF6B, CREB3L4, CREB1, CREB3L1, CREM, CREB3 |
| Tissue | duodenum, liver, small.intestine |
| Tissue Specificity | Exclusively expressed in liver. Underexpressed in hepatocellular carcinoma tissues. {ECO:0000269|PubMed:11353085, ECO:0000269|PubMed:15800215}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs775653860 rs548714946 rs140312652 rs778428363 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:11353085}; Single-pass type II membrane protein {ECO:0000269|PubMed:11353085}.; [Processed cyclic AMP-responsive element-binding protein 3-like protein 3]: Nucleus {ECO:0000269|PubMed:30389664}. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. |
| Mouse PG classification | NA |
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