| Gene Information | |
|---|---|
| Gene Name | CRBN |
| Organism | Homo sapiens (Human) |
| Gene Length | 442 |
| Protein Names | Protein cereblon |
| Target Name | protein cereblon |
| Target Type | NA |
| Gene Age | 55 ( ENSG00000113851 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96SW2 |
| Gene Card | CRBN |
| Uniprot ID | Q96SW2 |
| Pfam | PF02190; PF03226 |
| In ASD | no |
| Allosteric Prediction | yes (0.029992716) |
| Ortholog in Animals | Alpaca_ CRBN ( ortholog_one2one ) Dog_ CRBN ( ortholog_one2one ) GuineaPig_ CRBN ( ortholog_one2one ) Macaque_ CRBN ( ortholog_one2one ) Mouse_ Crbn ( ortholog_one2one ) Pig_ CRBN ( ortholog_one2one ) Rat_ Crbn ( ortholog_one2one ) Rabbit_ CRBN ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Highly expressed in brain. {ECO:0000269|PubMed:15557513, ECO:0000269|PubMed:17380424}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002505(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4M91 (X-ray 1.10A ) 4TZ4 (X-ray 3.01A ) 5FQD (X-ray 2.45A ) 5HXB (X-ray 3.60A ) 5V3O (X-ray 3.20A ) 6BN7 (X-ray 3.50A ) 6BN8 (X-ray 3.99A ) 6BN9 (X-ray 4.38A ) 6BNB (X-ray 6.34A ) 6BOY (X-ray 3.33A ) 6H0F (X-ray 3.25A ) 6H0G (X-ray 4.25A ) 6UML (X-ray 3.58A ) 6XK9 (X-ray 3.64A ) 7BQU (X-ray 1.90A ) 7BQV (X-ray 1.80A ) 7LPS (X-ray 3.78A ) 8CVP (EM 3.40A ) 8D7U (EM 3.10A ) 8D7V (EM 3.20A ) 8D7W (EM 3.10A ) 8D7X (EM 3.40A ) 8D7Y (EM 3.40A ) 8D7Z (EM 3.10A ) 8D80 (EM 3.60A ) 8D81 (EM 3.90A ) |
| DBSNP | rs797045036 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:20223979}. Nucleus {ECO:0000269|PubMed:20223979}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. |
| Mouse PG classification | LPG |
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