| Gene Information | |
|---|---|
| Gene Name | CRB3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 120 |
| Protein Names | Protein crumbs homolog 3 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000130545 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9BUF7 |
| Gene Card | CRB3 |
| Uniprot ID | Q9BUF7 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.364689645) |
| Ortholog in Animals | Alpaca_ CRB3 ( ortholog_one2one ) Dog_ CRB3 ( ortholog_one2one ) GuineaPig_ CRB3 ( ortholog_one2one ) Macaque_ CRB3 ( ortholog_one2one ) Mouse_ Crb3 ( ortholog_one2one ) Pig_ CRB3 ( ortholog_one2one ) Rat_ Crb3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SCARF1, CRB2, SCARF2 |
| Tissue | NA |
| Tissue Specificity | Preferentially expressed in epithelial tissues (PubMed:14718572). Expressed at high levels in lung, kidney, and colon (PubMed:12527193, PubMed:14718572). Expressed at high levels in retina, colon and mammary glands (PubMed:12527193). Moderately expressed in liver, spleen, pancreas and prostate (PubMed:12527193). Moderately to weakly expressed in the placenta (PubMed:14718572, PubMed:12527193). Weakly expressed in skeletal muscle and small intestine (PubMed:14718572). {ECO:0000269|PubMed:12527193, ECO:0000269|PubMed:14718572}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5I7Z (X-ray 1.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | Apical cell membrane {ECO:0000269|PubMed:12527193, ECO:0000269|PubMed:12771187, ECO:0000269|PubMed:14718572}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, tight junction {ECO:0000269|PubMed:12527193}. Note=Localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of epithelial cells. {ECO:0000269|PubMed:14718572}. |
| Mouse PG classification | NA |
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