| Gene Information | |
|---|---|
| Gene Name | CRB2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1285 |
| Protein Names | Protein crumbs homolog 2 (Crumbs-like protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000148204 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q5IJ48 |
| Gene Card | CRB2 |
| Uniprot ID | Q5IJ48 |
| Pfam | PF00008; PF12661; PF02210 |
| In ASD | no |
| Allosteric Prediction | no (-0.963398257) |
| Ortholog in Animals | Alpaca_ CRB2 ( ortholog_one2one ) Dog_ CRB2 ( ortholog_one2one ) GuineaPig_ CRB2 ( ortholog_one2one ) Macaque_ CRB2 ( ortholog_one2one ) Mouse_ Crb2 ( ortholog_one2one ) Pig_ CRB2 ( ortholog_one2one ) Rat_ Crb2 ( ortholog_one2one ) |
| Ohnologs | CRB1 |
| Paralogs | SCARF1, SCARF2, CRB3 |
| Tissue | NA |
| Tissue Specificity | Expressed in glomeruli, podocytes of the glomerular capillary loops, and parietal glomerular epithelial cells in the kidney (at protein level) (PubMed:29473663, PubMed:27942854). Expressed in retina, fetal eye and brain (PubMed:15851977). Also expressed in kidney, RPE/choroid, and at low levels in lung, placenta, and heart (PubMed:15851977). {ECO:0000269|PubMed:15851977, ECO:0000269|PubMed:27942854, ECO:0000269|PubMed:29473663}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2WO6 (X-ray 2.50A ) |
| DBSNP | rs73571404 rs2808415 rs542211566 rs1105223 rs1105222 rs199679542 rs144803819 rs370059953 rs145286619 rs879255250 rs202128397 rs879255252 rs730880377 rs730880300 rs372093386 rs2488602 rs757353722 rs765676223 rs1463148582 rs868484209 rs73571431 rs1219047251 rs147412276 |
| Subcellular location [CC] | [Isoform 1]: Apical cell membrane {ECO:0000250|UniProtKB:Q80YA8}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q80YA8}. Cell junction {ECO:0000250|UniProtKB:Q80YA8}. Note=O-glucosylation is required for localization at the apical plasma membrane (By similarity). Distributed in a complex anisotropic pattern on apical cell edges: the level of CRB2 on a cell edge is inversely correlated with the level of MYH10/myosin-IIB (By similarity). {ECO:0000250|UniProtKB:Q80YA8}.; [Isoform 2]: Secreted {ECO:0000255}. |
| Mouse PG classification | LPG |
| click here to return to the previous page | |