| Gene Information | |
|---|---|
| Gene Name | EXOSC8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 276 |
| Protein Names | Exosome complex component RRP43 (Exosome component 8) (Opa-interacting protein 2) (OIP-2) (Ribosomal RNA-processing protein 43) (p9) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000120699 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | Q96B26 |
| Gene Card | EXOSC8 |
| Uniprot ID | Q96B26 |
| Pfam | PF01138; PF03725 |
| In ASD | no |
| Allosteric Prediction | no (-0.762817307) |
| Ortholog in Animals | Alpaca_ EXOSC8 ( ortholog_one2one ) Dog_ EXOSC8 ( ortholog_one2one ) GuineaPig_ EXOSC8 ( ortholog_one2one ) Macaque_ EXOSC8 ( ortholog_one2one ) Mouse_ Exosc8 ( ortholog_one2one ) Pig_ EXOSC8 ( ortholog_one2one ) Rat_ Exosc8 ( ortholog_one2one ) Rabbit_ EXOSC8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | EXOSC7, EXOSC9 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.025660(Chimpanzee);0.127113(Mouse);NULL(Rat);0.070738(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2NN6 (X-ray 3.35A ) 6D6Q (EM 3.45A ) 6D6R (EM 3.45A ) 6H25 (EM 3.80A ) |
| DBSNP | rs606231285 rs36027220 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17545563}. Nucleus {ECO:0000269|PubMed:17545563}. Nucleus, nucleolus {ECO:0000250}. |
| Mouse PG classification | NA |
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