| Gene Information | |
|---|---|
| Gene Name | CRB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1406 |
| Protein Names | Protein crumbs homolog 1 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000134376 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P82279 |
| Gene Card | CRB1 |
| Uniprot ID | P82279 |
| Pfam | PF00008; PF12661; PF02210 |
| In ASD | no |
| Allosteric Prediction | no (-0.674962981) |
| Ortholog in Animals | Alpaca_ CRB1 ( ortholog_one2one ) Dog_ CRB1 ( ortholog_one2one ) Macaque_ CRB1 ( ortholog_one2one ) Mouse_ Crb1 ( ortholog_one2one ) Pig_ CRB1 ( ortholog_one2one ) Rat_ Crb1 ( ortholog_one2one ) Rabbit_ CRB1 ( ortholog_one2one ) |
| Ohnologs | CRB2 |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Preferential expression in retina, also expressed in brain, testis, fetal brain and fetal eye (PubMed:15914641). Expressed at the outer limiting membrane and apical to adherens junctions in the retina (PubMed:15914641). {ECO:0000269|PubMed:15914641}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4UU5 (X-ray 1.23A ) |
| DBSNP | rs1460946384 rs145141811 rs62636262 rs62635651 rs137853138 rs764256655 rs62645749 rs114846212 rs62635652 rs62636263 rs779835125 rs587783015 rs62645754 rs62636288 rs1571522690 rs954595597 rs963201816 rs62636264 rs777377174 rs1664299898 rs113082791 rs1266363944 rs1664322968 rs1471328495 rs62636286 rs62636266 rs62645755 rs145282040 rs1664649015 rs62636267 rs28939720 rs62635653 rs896160584 rs62635654 rs375040930 rs62636287 rs1433518605 rs142857810 rs116471343 rs62636289 rs539189291 rs776591659 rs62636271 rs62635658 rs62636290 rs114052315 rs114630940 rs1411345985 rs62645747 rs62645748 rs557111131 rs1409740542 rs62636274 rs62635656 rs62635657 rs62635659 rs62635659 rs62636275 rs62636276 rs62636276 rs1414707912 rs1665099725 rs917768074 rs62636291 rs574742644 rs1391910861 rs62636281 rs62635649 rs62636285 rs377543137 rs200469148 rs200573274 |
| Subcellular location [CC] | [Isoform 1]: Apical cell membrane {ECO:0000250|UniProtKB:Q8VHS2}; Single-pass type I membrane protein {ECO:0000255}. Secreted {ECO:0000305}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q8VHS2}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q8VHS2}.; [Isoform 2]: Secreted. |
| Mouse PG classification | HPG |
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