| Gene Information | |
|---|---|
| Gene Name | CR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1033 |
| Protein Names | Complement receptor type 2 (Cr2) (Complement C3d receptor) (Epstein-Barr virus receptor) (EBV receptor) (CD antigen CD21) |
| Target Name | complement receptor type 2 |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000117322 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P20023 |
| Gene Card | CR2 |
| Uniprot ID | P20023 |
| Pfam | PF00084 |
| In ASD | no |
| Allosteric Prediction | yes (0.174022467) |
| Ortholog in Animals | Alpaca_ CR2 ( ortholog_one2one ) GuineaPig_ CR2 ( ortholog_one2one ) Macaque_ CR2 ( ortholog_one2one ) Mouse_ Cr2 ( ortholog_one2one ) Rat_ Cr2 ( ortholog_one2one ) Rabbit_ CR2 ( ortholog_one2one ) |
| Ohnologs | SVEP1 |
| Paralogs | CR1L, SUSD3, F13B, SELP, SEZ6L2, CFHR2, CFHR1, CSMD1, APOH, SELE, SRPX, SVEP1, SEZ6, C8A, CD55, CSMD2, PAPPA2, SUSD6, C4BPA, C9, CR1, PAPPA, SELL, CFB, CD46, C4BPB, C7, CSMD3, CFHR3, CFH, SEZ6L, CFHR4, CFHR5, SRPX2, C8B, PRF1, SUSD4, C6, C2 |
| Tissue | lymph.node, appendix, spleen, tonsil |
| Tissue Specificity | Mature B-lymphocytes, T-lymphocytes, pharyngeal epithelial cells, astrocytes and follicular dendritic cells of the spleen. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1GHQ (X-ray 2.04A ) 1LY2 (X-ray 1.80A ) 1W2R (X-ray - ) 1W2S (X-ray - ) 2ATY (X-ray - ) 2GSX (X-ray - ) 3OED (X-ray 3.16A ) |
| DBSNP | rs17615 rs17618 rs17617 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:1383329, ECO:0000269|PubMed:1702139}; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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