| Gene Information | |
|---|---|
| Gene Name | CR1L |
| Organism | Homo sapiens (Human) |
| Gene Length | 569 |
| Protein Names | Complement component receptor 1-like protein (Complement C4b-binding protein CR-1-like protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 55 ( ENSG00000197721 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q2VPA4 |
| Gene Card | CR1L |
| Uniprot ID | Q2VPA4 |
| Pfam | PF00084 |
| In ASD | no |
| Allosteric Prediction | no (-0.997614207) |
| Ortholog in Animals | Alpaca_ CR1L ( ortholog_one2one ) Macaque_ CR1L ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SUSD3, F13B, SELP, SEZ6L2, CFHR2, CFHR1, CSMD1, APOH, SELE, SRPX, SVEP1, SEZ6, C8A, CD55, CSMD2, PAPPA2, SUSD6, C4BPA, C9, CR1, PAPPA, SELL, CFB, CD46, C4BPB, CR2, C7, CSMD3, CFHR3, CFH, SEZ6L, CFHR4, CFHR5, SRPX2, C8B, PRF1, SUSD4, C6, C2 |
| Tissue | bone.marrow |
| Tissue Specificity | Expressed in fetal liver and to a lesser extent in fetal spleen and thymus. Expression appears to be limited to hematopoietic and fetal lymphoid tissue. {ECO:0000269|PubMed:14687939}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2296158 rs3085 rs12729569 rs6683902 rs2796257 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:14687939}. Membrane {ECO:0000269|PubMed:14687939}. Secreted {ECO:0000269|PubMed:14687939}. Note=Predominantly found in association with the membrane fraction, but also located in the cytoplasm and in the supernatant. |
| Mouse PG classification | NA |
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