| Gene Information | |
|---|---|
| Gene Name | CR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2039 |
| Protein Names | Complement receptor type 1 (C3b/C4b receptor) (CD antigen CD35) |
| Target Name | complement receptor type 1 |
| Target Type | Clinical trial target |
| Gene Age | 382 ( ENSG00000203710 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P17927 |
| Gene Card | CR1 |
| Uniprot ID | P17927 |
| Pfam | PF00084 |
| In ASD | no |
| Allosteric Prediction | yes (0.818619783) |
| Ortholog in Animals | Alpaca_ CR1 ( ortholog_one2one ) Dog_ CR1L ( ortholog_one2one ) Mouse_ Cr1l ( ortholog_one2one ) Rat_ Cr1l ( ortholog_one2one ) |
| Ohnologs | SVEP1 |
| Paralogs | CR1L, SUSD3, F13B, SELP, SEZ6L2, CFHR2, CFHR1, CSMD1, APOH, SELE, SRPX, SVEP1, SEZ6, C8A, CD55, CSMD2, PAPPA2, SUSD6, C4BPA, C9, PAPPA, SELL, CFB, CD46, C4BPB, CR2, C7, CSMD3, CFHR3, CFH, SEZ6L, CFHR4, CFHR5, SRPX2, C8B, PRF1, SUSD4, C6, C2 |
| Tissue | appendix, lymph.node, spleen, tonsil, whole.blood |
| Tissue Specificity | Present on erythrocytes, a subset of T cells, mature B cells, follicular dendritic cells, monocytes and granulocytes. {ECO:0000269|PubMed:1534036, ECO:0000269|PubMed:25742728, ECO:0000269|PubMed:6233222}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1GKG (NMR - ) 1GKN (NMR - ) 1PPQ (NMR - ) 2MCY (NMR - ) 2MCZ (NMR - ) 2Q7Z (X-ray - ) 5FO9 (X-ray 3.30A ) |
| DBSNP | rs2274567 rs3737002 rs17259045 rs17047660 rs17047661 rs4844609 rs6691117 rs3811381 rs2296160 |
| Subcellular location [CC] | Membrane {ECO:0000269|PubMed:1385479}; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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