| Gene Information | |
|---|---|
| Gene Name | CR |
| Organism | Homo sapiens (Human) |
| Gene Length | 381 |
| Protein Names | Complement decay-accelerating factor (CD antigen CD55) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P08174 |
| Gene Card | CD55 |
| Uniprot ID | P08174 |
| Pfam | PF00084 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed on the plasma membranes of all cell types that are in intimate contact with plasma complement proteins. It is also found on the surfaces of epithelial cells lining extracellular compartments, and variants of the molecule are present in body fluids and in extracellular matrix. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1H03 (X-ray 1.70A ) 1H04 (X-ray 2.00A ) 1H2P (X-ray 2.80A ) 1H2Q (X-ray 3.00A ) 1M11 (EM 16.00A ) 1NWV (NMR - ) 1OJV (X-ray 2.30A ) 1OJW (X-ray 2.30A ) 1OJY (X-ray 2.60A ) 1OK1 (X-ray 2.60A ) 1OK2 (X-ray 2.50A ) 1OK3 (X-ray 2.20A ) 1OK9 (X-ray 3.00A ) 1UOT (X-ray 3.00A ) 1UPN (EM 16.00A ) 2C8I (EM 14.00A ) 2QZD (EM - ) 2QZF (EM - ) 2QZH (EM 14.00A ) 3IYP (EM - ) 3J24 (EM 9.00A ) 5FOA (X-ray 4.19A ) 6ILJ (EM 3.60A ) 6ILK (EM 3.00A ) 6LA5 (EM 2.86A ) 7C9W (EM 3.60A ) 7DO4 (X-ray 3.20A ) 7VY5 (EM 3.15A ) 7VY6 (EM 3.02A ) |
| DBSNP | rs28371588 rs28371588 rs147474393 rs1135402914 rs60822373 rs199705465 rs1135402917 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform 3]: Secreted {ECO:0000269|PubMed:16503113}.; [Isoform 4]: Secreted {ECO:0000269|PubMed:16503113}.; [Isoform 5]: Secreted {ECO:0000269|PubMed:16503113}.; [Isoform 6]: Cell membrane {ECO:0000305|PubMed:16503113}; Lipid-anchor, GPI-anchor {ECO:0000305|PubMed:16503113}.; [Isoform 7]: Cell membrane {ECO:0000305|PubMed:16503113}; Lipid-anchor, GPI-anchor {ECO:0000305|PubMed:16503113}. |
| Mouse PG classification | NA |
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