| Gene Information | |
|---|---|
| Gene Name | CPZ |
| Organism | Homo sapiens (Human) |
| Gene Length | 652 |
| Protein Names | Carboxypeptidase Z (CPZ) (EC 3.4.17.-) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000109625 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q66K79 |
| Gene Card | CPZ |
| Uniprot ID | Q66K79 |
| Pfam | PF01392; PF00246 |
| In ASD | no |
| Allosteric Prediction | no (-0.300606971) |
| Ortholog in Animals | Alpaca_ CPZ ( ortholog_one2one ) Dog_ CPZ ( ortholog_one2one ) GuineaPig_ CPZ ( ortholog_one2one ) Macaque_ CPZ ( ortholog_one2one ) Mouse_ Cpz ( ortholog_one2one ) Pig_ CPZ ( ortholog_one2one ) Rat_ Cpz ( ortholog_one2one ) |
| Ohnologs | CPXM1, AEBP1, CPN1, CPXM2, CPE |
| Paralogs | CPXM2, CPD, AEBP1, CPN1, CPXM1, CPM, CPE |
| Tissue | NA |
| Tissue Specificity | In placenta, it is present within invasive trophoblasts and in the surrounding extracellular space. Also present in amnion cells, but is not readily apparent in the extracellular matrix of this cell type. Present in normal pituitary gland and neoplastic pituitary gland (especially POMC-, GH- and PRL-producing adenomas) (at protein level). Widely expressed. {ECO:0000269|PubMed:10671522, ECO:0000269|PubMed:12417617, ECO:0000269|PubMed:9099699}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2302583 rs34964084 rs35993494 rs7378066 rs9991535 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:10671522}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |