| Gene Information | |
|---|---|
| Gene Name | KARAP |
| Organism | Homo sapiens (Human) |
| Gene Length | 113 |
| Protein Names | TYRO protein tyrosine kinase-binding protein (DNAX-activation protein 12) (Killer-activating receptor-associated protein) (KAR-associated protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O43914 |
| Gene Card | TYROBP |
| Uniprot ID | O43914 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Expressed in hematological cells and tissues such as peripheral blood leukocytes and spleen. Also found in bone marrow, lymph nodes, placenta, lung and liver. Expressed at lower levels in different parts of the brain especially in the basal ganglia and corpus callosum. {ECO:0000269|PubMed:11922939}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2L34 (NMR - ) 2L35 (NMR - ) 4WO1 (X-ray 2.14A ) 4WOL (X-ray 1.77A ) 7Q5W (X-ray 2.20A ) |
| DBSNP | rs200649978 rs769635655 rs372140827 rs77782321 rs140188939 rs557854792 rs14714 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:9655483}; Single-pass type I membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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