| Gene Information | |
|---|---|
| Gene Name | MARCHF2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 246 |
| Protein Names | E3 ubiquitin-protein ligase MARCHF2 (EC 2.3.2.27) (Membrane-associated RING finger protein 2) (Membrane-associated RING-CH protein II) (MARCH-II) (RING finger protein 172) (RING-type E3 ubiquitin transferase MARCHF2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000099785 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9P0N8 |
| Gene Card | MARCHF2 |
| Uniprot ID | Q9P0N8 |
| Pfam | PF12906 |
| In ASD | no |
| Allosteric Prediction | no (-0.581211991) |
| Ortholog in Animals | Alpaca_ MARCHF2 ( ortholog_one2one ) Dog_ MARCHF2 ( ortholog_one2one ) GuineaPig_ MARCHF2 ( ortholog_one2one ) Macaque_ MARCHF2 ( ortholog_one2one ) Mouse_ Marchf2 ( ortholog_one2one ) Pig_ MARCHF2 ( ortholog_one2one ) Rat_ Marchf2 ( ortholog_one2one ) Rabbit_ MARCHF2 ( ortholog_one2one ) |
| Ohnologs | MARCHF3 |
| Paralogs | MARCHF8, MARCHF9, MARCHF4, MARCHF1, MARCHF11, MARCHF3 |
| Tissue | NA |
| Tissue Specificity | Broadly expressed. {ECO:0000269|PubMed:14722266}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1133893 rs34099346 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:14722266}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5I0I2}. Lysosome membrane {ECO:0000269|PubMed:14722266}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:23166351}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5I0I2}. Golgi apparatus membrane {ECO:0000269|PubMed:23818989}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:32935379}. Cell membrane {ECO:0000269|PubMed:32935379}; Multi-pass membrane protein {ECO:0000269|PubMed:32935379}. |
| Mouse PG classification | NA |
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