| Gene Information | |
|---|---|
| Gene Name | PIBF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 757 |
| Protein Names | Progesterone-induced-blocking factor 1 (PIBF) (Centrosomal protein of 90 kDa) (CEP90) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000083535 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8WXW3 |
| Gene Card | PIBF1 |
| Uniprot ID | Q8WXW3 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.65122091) |
| Ortholog in Animals | Alpaca_ PIBF1 ( ortholog_one2one ) Dog_ PIBF1 ( ortholog_one2one ) GuineaPig_ PIBF1 ( ortholog_one2one ) Macaque_ PIBF1 ( ortholog_one2one ) Mouse_ Pibf1 ( ortholog_one2one ) Pig_ PIBF1 ( ortholog_one2one ) Rat_ Pibf1 ( ortholog_one2one ) Rabbit_ PIBF1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at highest levels in testis. Moderate expression is detected in spleen, thymus, prostate, ovary, small intestine, and colon (PubMed:11935316). Expressed in the first trimester pregnancy decidua (PubMed:12516630). Localized to extravillous cytotrophoblast (at protein level). Also found in syncytiotrophoblast and part of the villous cytotrophoblast. Isoform 1 is expressed in first trimester and term villous trophoblast; trophoblast cells can additionally express other isoforms (PubMed:18817979). Overexpressed in solid tumors from stomach and uterus and in cells from ovary, cervical, breast, lymphoma and leukemia cancer (PubMed:25218441). {ECO:0000269|PubMed:11935316, ECO:0000269|PubMed:12516630, ECO:0000269|PubMed:18817979, ECO:0000305|PubMed:25218441}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs865883692 rs1372000 rs17089782 rs11544631 rs987735817 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cytoplasm {ECO:0000269|PubMed:25218441}. Secreted {ECO:0000269|PubMed:25218441}. Note=In progesterone-treated astrocytoma cells a 57 kDa protein and isoform 1 (90 kDa) have been described, both being located in the intracellular medium and secreted. Respective predominant forms are isoform 1 in the intracellular and the 57 kDa protein in the extracellular medium (PubMed:25218441). {ECO:0000269|PubMed:25218441}.; [Isoform 1]: Nucleus {ECO:0000269|PubMed:14634107, ECO:0000269|PubMed:25218441}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15305375}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:21224392, ECO:0000269|PubMed:26297806}. Secreted {ECO:0000269|PubMed:25218441}. Note=Localizes to centriolar satellites throughout the cell cycle. {ECO:0000269|PubMed:26297806}.; [Isoform 4]: Secreted {ECO:0000269|PubMed:14634107, ECO:0000269|PubMed:3863495}. Note=Secreted by progesterone-treated lymphocytes (PubMed:14634107). {ECO:0000269|PubMed:14634107}. |
| Mouse PG classification | NA |
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