| Gene Information | |
|---|---|
| Gene Name | CPS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1500 |
| Protein Names | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) |
| Target Name | carbamoyl-phosphate synthase [ammonia], mitochondrial |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000021826 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P31327 |
| Gene Card | CPS1 |
| Uniprot ID | P31327 |
| Pfam | PF02786; PF02787; PF00988; PF00117; PF02142 |
| In ASD | yes |
| Allosteric Prediction | yes (1.10787973) |
| Ortholog in Animals | Alpaca_ CPS1 ( ortholog_one2one ) Dog_ CPS1 ( ortholog_one2one ) GuineaPig_ CPS1 ( ortholog_one2one ) Macaque_ CPS1 ( ortholog_one2one ) Mouse_ Cps1 ( ortholog_one2one ) Pig_ CPS1 ( ortholog_one2one ) Rat_ Cps1 ( ortholog_one2one ) Rabbit_ CPS1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CAD, OTC |
| Tissue | liver, small.intestine |
| Tissue Specificity | Primarily in the liver and small intestine. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2YVQ (X-ray 1.98A ) 4UTR (X-ray 2.90A ) 4UTV (X-ray 2.40A ) 4UTX (X-ray 3.10A ) 4UTZ (X-ray 3.30A ) 4UU7 (X-ray 3.00A ) 4UU8 (X-ray 2.90A ) 4UUA (X-ray 2.80A ) 4UUB (X-ray 2.90A ) 5DOT (X-ray 2.40A ) 5DOU (X-ray 2.60A ) 5OJO (X-ray 3.10A ) 6UEL (X-ray 1.90A ) 6W2J (X-ray 2.62A ) |
| DBSNP | rs375979196 rs1265394565 rs1553509297 rs1553509661 rs767905306 rs752902711 rs1471393474 rs753751183 rs973321068 rs775920437 rs1273594946 rs28940283 rs1047883 rs1047883 rs1472190012 rs149930500 rs201407486 rs760895692 rs778766382 rs772497399 rs772497399 rs371350538 rs1250316045 rs121912592 rs1242028775 rs1553512642 rs777233486 rs1048119191 rs1553512962 rs1275599086 rs1553512974 rs757205958 rs142693704 rs1248368809 rs369061090 rs752339705 rs758724746 rs1553513429 rs201716417 rs201716417 rs201716417 rs1553513861 rs1553513864 rs772782772 rs1553513870 rs1015051007 rs767694281 rs147062907 rs1388955593 rs754706559 rs765484849 rs760714614 rs537170841 rs1191587211 rs955666400 rs534815243 rs121912595 rs757059355 rs121912595 rs1553516442 rs1553516443 rs990390709 rs1404696893 rs749238466 rs1437651658 rs1241423400 rs770471782 rs1392559810 rs1280211937 rs766125631 rs149518280 rs1319489001 rs141373204 rs778117194 rs750670270 rs1047886 rs1047887 rs372645328 rs140578009 rs1245373037 rs1392934477 rs1047891 rs1202306773 rs933813349 rs1553519513 |
| Subcellular location [CC] | Mitochondrion {ECO:0000269|PubMed:22002106}. Nucleus, nucleolus {ECO:0000269|PubMed:22002106}. |
| Mouse PG classification | NA |
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