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Gene Information
Gene Name
CPP32
Organism
Homo sapiens (Human)
Gene Length
277
Protein Names
Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
Target Name
NA
Target Type
NA
Gene Age
NA
Evolutionary Stage
NA
AlphaFoldDB
P42574
Gene Card
CASP3
Uniprot ID
P42574
Pfam
NA
In ASD
yes
Allosteric Prediction
NA
Ortholog in Animals
NA
Ohnologs
NA
Paralogs
NA
Tissue
NA
Tissue Specificity
Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system. {ECO:0000269|PubMed:7983002}.
Pharmacological Animal Models
NULL(Chimpanzee);NULL(Mouse);0.034206(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
1CP3
(X-ray
2.30A
)
1GFW
(X-ray
2.80A
)
1I3O
(X-ray
2.70A
)
1NME
(X-ray
1.60A
)
1NMQ
(X-ray
2.40A
)
1NMS
(X-ray
1.70A
)
1PAU
(X-ray
2.50A
)
1QX3
(X-ray
1.90A
)
1RE1
(X-ray
2.50A
)
1RHJ
(X-ray
2.20A
)
1RHK
(X-ray
2.50A
)
1RHM
(X-ray
2.50A
)
1RHQ
(X-ray
3.00A
)
1RHR
(X-ray
3.00A
)
1RHU
(X-ray
2.51A
)
2C1E
(X-ray
1.77A
)
2C2K
(X-ray
1.87A
)
2C2M
(X-ray
1.94A
)
2C2O
(X-ray
2.45A
)
2CDR
(X-ray
1.70A
)
2CJX
(X-ray
1.70A
)
2CJY
(X-ray
1.67A
)
2CNK
(X-ray
1.75A
)
2CNL
(X-ray
1.67A
)
2CNN
(X-ray
1.70A
)
2CNO
(X-ray
1.95A
)
2DKO
(X-ray
1.06A
)
2H5I
(X-ray
1.69A
)
2H5J
(X-ray
2.00A
)
2H65
(X-ray
2.30A
)
2J30
(X-ray
1.40A
)
2J31
(X-ray
1.50A
)
2J32
(X-ray
1.30A
)
2J33
(X-ray
2.00A
)
2XYG
(X-ray
1.54A
)
2XYH
(X-ray
1.89A
)
2XYP
(X-ray
1.86A
)
2XZD
(X-ray
2.10A
)
2XZT
(X-ray
2.70A
)
2Y0B
(X-ray
2.10A
)
3DEH
(X-ray
2.50A
)
3DEI
(X-ray
2.80A
)
3DEJ
(X-ray
2.60A
)
3DEK
(X-ray
2.40A
)
3EDQ
(X-ray
1.61A
)
3GJQ
(X-ray
2.60A
)
3GJR
(X-ray
2.20A
)
3GJS
(X-ray
1.90A
)
3GJT
(X-ray
2.20A
)
3H0E
(X-ray
2.00A
)
3ITN
(X-ray
1.63A
)
3KJF
(X-ray
2.00A
)
3PCX
(X-ray
1.50A
)
3PD0
(X-ray
2.00A
)
3PD1
(X-ray
1.62A
)
4DCJ
(X-ray
1.70A
)
4DCO
(X-ray
1.70A
)
4DCP
(X-ray
1.70A
)
4EHA
(X-ray
1.70A
)
4EHD
(X-ray
1.58A
)
4EHF
(X-ray
1.66A
)
4EHH
(X-ray
1.78A
)
4EHK
(X-ray
1.67A
)
4EHL
(X-ray
1.80A
)
4EHN
(X-ray
1.69A
)
4JJE
(X-ray
1.48A
)
4JQY
(X-ray
2.50A
)
4JQZ
(X-ray
2.89A
)
4JR0
(X-ray
1.80A
)
4PRY
(X-ray
1.70A
)
4PS0
(X-ray
1.63A
)
4QTX
(X-ray
1.97A
)
4QTY
(X-ray
1.60A
)
4QU0
(X-ray
1.95A
)
4QU5
(X-ray
1.91A
)
4QU8
(X-ray
1.72A
)
4QU9
(X-ray
1.56A
)
4QUA
(X-ray
1.89A
)
4QUB
(X-ray
1.69A
)
4QUD
(X-ray
2.00A
)
4QUE
(X-ray
1.84A
)
4QUG
(X-ray
1.92A
)
4QUH
(X-ray
1.76A
)
4QUI
(X-ray
1.76A
)
4QUJ
(X-ray
1.50A
)
4QUL
(X-ray
1.90A
)
5I9B
(X-ray
1.80A
)
5I9T
(X-ray
1.95A
)
5IAB
(X-ray
1.79A
)
5IAE
(X-ray
1.55A
)
5IAG
(X-ray
1.98A
)
5IAJ
(X-ray
1.58A
)
5IAK
(X-ray
1.82A
)
5IAN
(X-ray
2.70A
)
5IAR
(X-ray
1.76A
)
5IAS
(X-ray
1.54A
)
5IBC
(X-ray
1.66A
)
5IBP
(X-ray
1.38A
)
5IBR
(X-ray
1.74A
)
5IC4
(X-ray
2.65A
)
DBSNP
rs35578277
rs1049210
Subcellular location [CC]
Cytoplasm {ECO:0000269|PubMed:15003516}.
Mouse PG classification
NA
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