| Gene Information | |
|---|---|
| Gene Name | XRCC4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 336 |
| Protein Names | DNA repair protein XRCC4 (hXRCC4) (X-ray repair cross-complementing protein 4) [Cleaved into: Protein XRCC4, C-terminus (XRCC4/C)] |
| Target Name | dna repair protein xrcc4 |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000152422 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q13426 |
| Gene Card | XRCC4 |
| Uniprot ID | Q13426 |
| Pfam | PF06632 |
| In ASD | no |
| Allosteric Prediction | yes (0.369241602) |
| Ortholog in Animals | Alpaca_ XRCC4 ( ortholog_one2one ) Dog_ XRCC4 ( ortholog_one2one ) GuineaPig_ XRCC4 ( ortholog_one2one ) Macaque_ XRCC4 ( ortholog_one2one ) Mouse_ Xrcc4 ( ortholog_one2one ) Rat_ Xrcc4 ( ortholog_one2one ) Rabbit_ XRCC4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:8548796}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1FU1 (X-ray 2.70A ) 1IK9 (X-ray 2.30A ) 3II6 (X-ray 2.40A ) 3MUD (X-ray 2.20A ) 3Q4F (X-ray 5.50A ) 3RWR (X-ray 3.94A ) 3SR2 (X-ray 3.97A ) 3W03 (X-ray 8.49A ) 4XA4 (X-ray 2.33A ) 5CHX (X-ray 2.30A ) 5CJ0 (X-ray 2.30A ) 5CJ4 (X-ray 3.10A ) 5E50 (X-ray 1.38A ) 5WJ7 (X-ray 2.50A ) 5WLZ (X-ray 3.50A ) 6ABO (X-ray 2.65A ) 7LSY (EM 8.40A ) 7LT3 (EM 4.60A ) 7M3P (X-ray 2.00A ) 7NFC (EM 4.14A ) 7NFE (EM 4.29A ) |
| DBSNP | rs28383138 rs587779351 rs28383151 rs28360135 rs28360136 rs797045017 rs2974446 rs3734091 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:16478998, ECO:0000269|PubMed:21982441, ECO:0000269|PubMed:24984242, ECO:0000269|PubMed:25597996, ECO:0000269|PubMed:25934149, ECO:0000269|PubMed:33725486, ECO:0000269|PubMed:9259561}. Chromosome {ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:27437582, ECO:0000269|PubMed:31548606}. Note=Localizes to site of double-strand breaks. {ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:27437582}.; [Protein XRCC4, C-terminus]: Cytoplasm {ECO:0000269|PubMed:33725486}. Note=Translocates from the nucleus to the cytoplasm following cleavage by caspase-3 (CASP3). {ECO:0000269|PubMed:33725486}. |
| Mouse PG classification | NA |
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