| Gene Information | |
|---|---|
| Gene Name | DYNLL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 89 |
| Protein Names | Dynein light chain 1, cytoplasmic (8 kDa dynein light chain) (DLC8) (Dynein light chain LC8-type 1) (Protein inhibitor of neuronal nitric oxide synthase) (PIN) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000088986 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P63167 |
| Gene Card | DYNLL1 |
| Uniprot ID | P63167 |
| Pfam | PF01221 |
| In ASD | no |
| Allosteric Prediction | no (-0.675305938) |
| Ortholog in Animals | Alpaca_ DYNLL1 ( ortholog_one2one ) Dog_ DYNLL1 ( ortholog_one2one ) GuineaPig_ DYNLL1 ( ortholog_one2one ) Macaque_ DYNLL1 ( ortholog_one2one ) Mouse_ Dynll1 ( ortholog_one2one ) Pig_ DYNLL1 ( ortholog_one2one ) Rat_ Dynll1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DYNLL2 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous (PubMed:8628263). Expressed in testis (PubMed:22965910). {ECO:0000269|PubMed:22965910, ECO:0000269|PubMed:8628263}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002419(Rat);0.053061(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1CMI (X-ray 2.50A ) 3ZKE (X-ray 2.20A ) 3ZKF (X-ray 2.60A ) 6GZJ (X-ray 1.98A ) 6GZL (X-ray 1.95A ) 6RLB (EM 4.50A ) 6SC2 (EM 3.90A ) 7D35 (X-ray 2.40A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20921139}. Nucleus {ECO:0000269|PubMed:15891768}. Mitochondrion {ECO:0000269|PubMed:18084006}. Note=Upon induction of apoptosis translocates together with BCL2L11 to mitochondria. {ECO:0000269|PubMed:18084006}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |