Gene Information
Gene NameCEACAM1
OrganismHomo sapiens (Human)
Gene Length526
Protein NamesCarcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (CD antigen CD66a)
Target Namebiliary glycoprotein 1
Target TypeClinical trial target
Gene Age168 ( ENSG00000079385 )
Evolutionary StageEumetazoa
AlphaFoldDBP13688
Gene CardCEACAM1
Uniprot IDP13688
PfamPF00047; PF13895; PF07686
In ASDno
Allosteric Predictionyes (0.141489491)
Ortholog in AnimalsAlpaca_ CEACAM1 ( ortholog_one2one )
Dog_ CEACAM1 ( ortholog_many2many )
Macaque_ CEACAM1 ( ortholog_one2one )
Mouse_ Ceacam10 ( ortholog_many2many )
Mouse_ Ceacam1 ( ortholog_many2many )
Mouse_ Ceacam2 ( ortholog_many2many )
Rat_ Ceacam1 ( ortholog_many2many )
Rat_ Ceacam4 ( ortholog_many2many )
Rat_ Ceacam6 ( ortholog_many2many )
OhnologsNA
ParalogsCEACAM19, HEPACAM2, HEPACAM, VSTM5, CEACAM3, CEACAM6, CEACAM5, CEACAM7, CEACAM8, PSG1, PSG8, PSG9, PSG3, PSG7, PSG11, PSG2, PSG4, PSG5, PSG6, CEACAM4, CEACAM21, CEACAM16, CEACAM20, CEACAM18
TissueNA
Tissue SpecificityExpressed in columnar epithelial cells of the colon (at protein level) (PubMed:10436421). The predominant forms expressed by T cells are those containing a long cytoplasmic domain (PubMed:18424730). Expressed in granulocytes and lymphocytes. Leukocytes only express isoforms 6 and isoform 1 (PubMed:11994468). {ECO:0000269|PubMed:10436421, ECO:0000269|PubMed:11994468, ECO:0000269|PubMed:18424730}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2GK2  (X-ray  2.20A  )  4QXW  (X-ray  2.04A  )  4WHD  (X-ray  2.50A  )  5DZL  (X-ray  3.40A  )  6AW2  (X-ray  2.68A  )  6GBG  (X-ray  2.80A  )  6GBH  (X-ray  2.59A  )  6V3P  (X-ray  3.25A  )  6XNO  (X-ray  1.90A  )  6XNT  (X-ray  3.10A  )  6XNW  (X-ray  1.90A  )  6XO1  (X-ray  1.76A  )  7MU8  (X-ray  1.70A  )  7RPP  (X-ray  2.20A  ) 
DBSNP rs8111171  rs8110904  rs8111468  rs41355544 
Subcellular location [CC][Isoform 1]: Cell membrane {ECO:0000250|UniProtKB:P16573};
Single-pass type I membrane protein {ECO:0000250|UniProtKB:P16573}. Lateral cell membrane {ECO:0000250|UniProtKB:P16573}. Apical cell membrane {ECO:0000250|UniProtKB:P16573}. Basal cell membrane {ECO:0000250|UniProtKB:P16573}. Cell junction {ECO:0000269|PubMed:16291724}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P16573}. Note=Canalicular domain of hepatocyte plasma membranes. Found as a mixture of monomer, dimer and oligomer in the plasma membrane. Occurs predominantly as cis-dimers and/or small cis-oligomers in the cell junction regions. Found as dimer in the solution. Predominantly localized to the lateral cell membranes. {ECO:0000250|UniProtKB:P16573}.;
[Isoform 2]: Secreted {ECO:0000269|PubMed:2025273}.;
[Isoform 3]: Secreted {ECO:0000269|PubMed:2025273}.;
[Isoform 4]: Secreted {ECO:0000269|PubMed:2025273}.;
[Isoform 5]: Cell membrane;
Single-pass type I membrane protein.;
[Isoform 6]: Cell membrane;
Single-pass type I membrane protein.;
[Isoform 7]: Cell membrane;
Single-pass type I membrane protein.;
[Isoform 8]: Cell membrane {ECO:0000269|PubMed:14522961};
Single-pass type I membrane protein {ECO:0000250|UniProtKB:P16573}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:14522961}. Lateral cell membrane {ECO:0000250|UniProtKB:P16573}. Apical cell membrane {ECO:0000250|UniProtKB:P16573}. Basal cell membrane {ECO:0000250|UniProtKB:P16573}. Cell junction {ECO:0000269|PubMed:8018919}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P16573}. Note=Predominantly localized to the lateral cell membranes. Found as a mixture of monomer, dimer and oligomer in the plasma membrane. Occurs predominantly as cis-dimers and/or small cis-oligomers in the cell junction regions (By similarity). Co-localizes with ANXA2 in secretory vesicles and with S100A10/p11 at the plasma membrane (PubMed:14522961). {ECO:0000250|UniProtKB:P16573, ECO:0000269|PubMed:14522961}.;
Cell projection, microvillus membrane {ECO:0000250|UniProtKB:P31809};
Single-pass type I membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:10436421};
Single-pass type I membrane protein {ECO:0000305}. Note=Localized to the apical glycocalyx surface (PubMed:10436421). Colocalizes with CEACAM20 at the apical brush border of intestinal cells. {ECO:0000250|UniProtKB:P31809, ECO:0000269|PubMed:10436421}.
Mouse PG classificationNA
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