| Gene Information | |
|---|---|
| Gene Name | CPEB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 566 |
| Protein Names | Cytoplasmic polyadenylation element-binding protein 1 (CPE-BP1) (CPE-binding protein 1) (h-CPEB) (hCPEB-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000214575 ) 3 ( ENSG00000277445 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9BZB8 |
| Gene Card | CPEB1 |
| Uniprot ID | Q9BZB8 |
| Pfam | PF16368; PF16366; PF16367 |
| In ASD | no |
| Allosteric Prediction | no (-0.482641623) |
| Ortholog in Animals | Alpaca_ CPEB1 ( ortholog_one2one ) Dog_ CPEB1 ( ortholog_one2one ) GuineaPig_ CPEB1 ( ortholog_one2one ) Macaque_ CPEB1 ( ortholog_one2one ) Mouse_ Cpeb1 ( ortholog_one2one ) Pig_ CPEB1 ( ortholog_one2one ) Rat_ Cpeb1 ( ortholog_one2one ) Rabbit_ CPEB1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CPEB2, CPEB4, CPEB3 |
| Tissue | testis |
| Tissue Specificity | Isoform 1 is expressed in immature oocytes, ovary, brain and heart. Isoform 2 is expressed in brain and heart. Isoform 3 and isoform 4 are expressed in brain. Expressed in breast tumors and several tumor cell lines. {ECO:0000269|PubMed:11223249, ECO:0000269|PubMed:15731006, ECO:0000269|PubMed:15966895}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2M13 (NMR - ) 2MKE (NMR - ) 2MKH (NMR - ) 2MKK (NMR - ) 2N1O (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:18923137, ECO:0000269|PubMed:28383716}. Nucleus {ECO:0000269|PubMed:18923137}. Cytoplasm, P-body. Cytoplasmic granule. Synapse. Membrane. Postsynaptic density {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=Continuously shuttling between nucleus and cytoplasm (PubMed:18923137). Also found in stress granules. Recruited to stress granules (SGs) upon arsenite treatment. In dendrites (By similarity). Localizes in synaptosomes at dendritic synapses of neurons (By similarity). Strongly enriched in postsynaptic density (PSD) fractions (By similarity). Transported into dendrites in a microtubule-dependent fashion and colocalizes in mRNA-containing particles with TACC3, dynein and kinesin (By similarity). Membrane-associated (By similarity). Colocalizes at excitatory synapses with members of the polyadenylation and translation complex factors (CPSF, APLP1, TACC3, AURKA, SYP, etc.) including CPE-containing RNAs (By similarity). {ECO:0000250, ECO:0000269|PubMed:18923137}. |
| Mouse PG classification | NA |
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