| Gene Information | |
|---|---|
| Gene Name | CPE |
| Organism | Homo sapiens (Human) |
| Gene Length | 476 |
| Protein Names | Carboxypeptidase E (CPE) (EC 3.4.17.10) (Carboxypeptidase H) (CPH) (Enkephalin convertase) (Prohormone-processing carboxypeptidase) |
| Target Name | carboxypeptidase e |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000109472 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P16870 |
| Gene Card | CPE |
| Uniprot ID | P16870 |
| Pfam | PF00246 |
| In ASD | no |
| Allosteric Prediction | yes (0.345812584) |
| Ortholog in Animals | Alpaca_ CPE ( ortholog_one2one ) Dog_ CPE ( ortholog_one2one ) GuineaPig_ CPE ( ortholog_one2one ) Macaque_ CPE ( ortholog_one2one ) Mouse_ Cpe ( ortholog_one2one ) Pig_ CPE ( ortholog_one2one ) Rat_ Cpe ( ortholog_one2one ) |
| Ohnologs | CPXM1, CPZ, CPN1, CPXM2 |
| Paralogs | CPXM2, CPD, AEBP1, CPN1, CPXM1, CPM, CPZ |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs34516004 rs541147146 |
| Subcellular location [CC] | [Isoform 1]: Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:Q00493}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:P15087}; Peripheral membrane protein {ECO:0000250|UniProtKB:P15087}. Secreted {ECO:0000250|UniProtKB:P15087}. Note=Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions. {ECO:0000250|UniProtKB:Q00493}. |
| Mouse PG classification | NA |
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