| Gene Information | |
|---|---|
| Gene Name | CPB2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 423 |
| Protein Names | Carboxypeptidase B2 (EC 3.4.17.20) (Carboxypeptidase U) (CPU) (Plasma carboxypeptidase B) (pCPB) (Thrombin-activable fibrinolysis inhibitor) (TAFI) |
| Target Name | carboxypeptidase b2 |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000080618 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q96IY4 |
| Gene Card | CPB2 |
| Uniprot ID | Q96IY4 |
| Pfam | PF00246; PF02244 |
| In ASD | no |
| Allosteric Prediction | yes (1.163211871) |
| Ortholog in Animals | Alpaca_ CPB2 ( ortholog_one2one ) Dog_ CPB2 ( ortholog_one2one ) GuineaPig_ CPB2 ( ortholog_one2one ) Mouse_ Cpb2 ( ortholog_one2one ) Pig_ CPB2 ( ortholog_one2one ) Rat_ Cpb2 ( ortholog_one2one ) Rabbit_ CPB2 ( ortholog_one2one ) |
| Ohnologs | CPB1, CPA3 |
| Paralogs | CPO, CPB1, CPA2, CPA6, CPA3, CPA4, CPA5, CPA1 |
| Tissue | liver, brain, lung |
| Tissue Specificity | Plasma; synthesized in the liver. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3D66 (X-ray 3.10A ) 3D67 (X-ray 3.40A ) 3D68 (X-ray 2.80A ) 3LMS (X-ray 2.50A ) 4P10 (X-ray 2.00A ) 5HVF (X-ray 2.85A ) 5HVG (X-ray 3.05A ) 5HVH (X-ray 3.00A ) 7NEE (X-ray 2.55A ) 7NEU (X-ray 2.80A ) |
| DBSNP | rs3742264 rs1926447 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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