| Gene Information | |
|---|---|
| Gene Name | COT |
| Organism | Homo sapiens (Human) |
| Gene Length | 467 |
| Protein Names | Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (Cancer Osaka thyroid oncogene) (Proto-oncogene c-Cot) (Serine/threonine-protein kinase cot) (Tumor progression locus 2) (TPL-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P41279 |
| Gene Card | MAP3K8 |
| Uniprot ID | P41279 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in several normal tissues and human tumor-derived cell lines. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4Y83 (X-ray 2.89A ) 4Y85 (X-ray 2.33A ) 5IU2 (X-ray 2.70A ) |
| DBSNP | rs3087944 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:1833717, ECO:0000269|PubMed:8226782}. |
| Mouse PG classification | NA |
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