| Gene Information | |
|---|---|
| Gene Name | CORTBP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1849 |
| Protein Names | SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (Proline-rich synapse-associated protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9UPX8 |
| Gene Card | SHANK2 |
| Uniprot ID | Q9UPX8 |
| Pfam | PF12796; PF17820; PF00536; PF07653 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Isoform 3 is present in epithelial colonic cells (at protein level). {ECO:0000269|PubMed:16293618, ECO:0000269|PubMed:17244609}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs868939163 |
| Subcellular location [CC] | Apical cell membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Synapse {ECO:0000250}. Postsynaptic density {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=Colocalizes with cortactin in growth cones in differentiating hippocampal neurons. Colocalized with PDE4D to the apical membrane of colonic crypt cells (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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