| Gene Information | |
|---|---|
| Gene Name | VDAC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 283 |
| Protein Names | Voltage-dependent anion-selective channel protein 1 (VDAC-1) (hVDAC1) (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) |
| Target Name | voltage-dependent anion-selective channel protein 1 |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000213585 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P21796 |
| Gene Card | VDAC1 |
| Uniprot ID | P21796 |
| Pfam | PF01459 |
| In ASD | no |
| Allosteric Prediction | yes (0.84044557) |
| Ortholog in Animals | Alpaca_ VDAC1 ( ortholog_one2one ) Dog_ VDAC1 ( ortholog_one2many ) Mouse_ Vdac1 ( ortholog_one2one ) Rat_ Vdac1 ( ortholog_one2many ) |
| Ohnologs | VDAC3, VDAC2, VDAC2P5 |
| Paralogs | VDAC2, VDAC3 |
| Tissue | NA |
| Tissue Specificity | Expressed in erythrocytes (at protein level) (PubMed:27641616). Expressed in heart, liver and skeletal muscle (PubMed:8420959). {ECO:0000269|PubMed:27641616, ECO:0000269|PubMed:8420959}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.019048(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2JK4 (X-ray 4.10A ) 2K4T (NMR - ) 5JDP (NMR - ) 5XDN (X-ray 3.15A ) 5XDO (X-ray 3.10A ) 6G6U (X-ray 2.74A ) 6G73 (X-ray 3.27A ) 6TIQ (NMR - ) 6TIR (NMR - ) 7QI2 (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Mitochondrion outer membrane {ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:31206022, ECO:0000269|PubMed:7539795}; Multi-pass membrane protein {ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:18832158, ECO:0000269|PubMed:27641616}. Cell membrane {ECO:0000269|PubMed:25168729, ECO:0000269|PubMed:25296756}; Multi-pass membrane protein {ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:18832158}. Membrane raft {ECO:0000269|PubMed:25168729}; Multi-pass membrane protein {ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:18832158}. |
| Mouse PG classification | NA |
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