| Gene Information | |
|---|---|
| Gene Name | COPS6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 327 |
| Protein Names | COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) (JAB1-containing signalosome subunit 6) (MOV34 homolog) (Vpr-interacting protein) (hVIP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000168090 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q7L5N1 |
| Gene Card | COPS6 |
| Uniprot ID | Q7L5N1 |
| Pfam | PF01398; PF13012 |
| In ASD | no |
| Allosteric Prediction | no (-0.428972008) |
| Ortholog in Animals | Alpaca_ COPS6 ( ortholog_one2one ) Dog_ COPS6 ( ortholog_one2one ) GuineaPig_ COPS6 ( ortholog_one2one ) Macaque_ COPS6 ( ortholog_one2one ) Mouse_ Cops6 ( ortholog_one2one ) Pig_ COPS6 ( ortholog_one2one ) Rat_ Cops6 ( ortholog_one2one ) Rabbit_ COPS6 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | EIF3F, PSMD7 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:9520381}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.090942(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4D10 (X-ray 3.80A ) 4D18 (X-ray 4.08A ) 4QFT (X-ray 1.76A ) 4R14 (X-ray 2.60A ) 4WSN (X-ray 5.50A ) 6R6H (EM 8.40A ) 6R7F (EM 8.20A ) 6R7H (EM 8.80A ) 6R7I (EM 5.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:9535219}. Cytoplasm {ECO:0000269|PubMed:9535219}.; Cytoplasm, perinuclear region {ECO:0000269|PubMed:9520381}. Note=(Microbial infection) The interaction with HIV-1 Vpr protein possibly leads its translocation to a perinuclear region. {ECO:0000269|PubMed:9520381}. |
| Mouse PG classification | NA |
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