| Gene Information | |
|---|---|
| Gene Name | COPS3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 423 |
| Protein Names | COP9 signalosome complex subunit 3 (SGN3) (Signalosome subunit 3) (JAB1-containing signalosome subunit 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000141030 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UNS2 |
| Gene Card | COPS3 |
| Uniprot ID | Q9UNS2 |
| Pfam | PF01399 |
| In ASD | no |
| Allosteric Prediction | no (-0.279402256) |
| Ortholog in Animals | Alpaca_ COPS3 ( ortholog_one2one ) Dog_ COPS3 ( ortholog_one2one ) GuineaPig_ COPS3 ( ortholog_one2one ) Macaque_ COPS3 ( ortholog_one2one ) Mouse_ Cops3 ( ortholog_one2one ) Pig_ COPS3 ( ortholog_one2one ) Rat_ Cops3 ( ortholog_one2one ) Rabbit_ COPS3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PSMD3 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Expressed at high level in heart and skeletal muscle. {ECO:0000269|PubMed:10191102}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.087642(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4D10 (X-ray 3.80A ) 4D18 (X-ray 4.08A ) 4WSN (X-ray 5.50A ) 6R6H (EM 8.40A ) 6R7F (EM 8.20A ) 6R7H (EM 8.80A ) 6R7I (EM 5.90A ) 6R7N (EM 6.50A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}. |
| Mouse PG classification | NA |
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