| Gene Information | |
|---|---|
| Gene Name | COPA |
| Organism | Homo sapiens (Human) |
| Gene Length | 1224 |
| Protein Names | Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000122218 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P53621 |
| Gene Card | COPA |
| Uniprot ID | P53621 |
| Pfam | PF12894; PF04053; PF06957; PF00400 |
| In ASD | no |
| Allosteric Prediction | yes (0.200594124) |
| Ortholog in Animals | Alpaca_ COPA ( ortholog_one2one ) Dog_ COPA ( ortholog_one2one ) GuineaPig_ COPA ( ortholog_one2one ) Macaque_ COPA ( ortholog_one2one ) Mouse_ Copa ( ortholog_one2one ) Pig_ COPA ( ortholog_one2one ) Rat_ Copa ( ortholog_one2one ) Rabbit_ COPA ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | COPB2 |
| Tissue | NA |
| Tissue Specificity | Uniformly expressed in a wide range of adult and fetal tissues. Xenin is found in gastric, duodenal and jejunal mucosa. Circulates in the blood. Seems to be confined to specific endocrine cells. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.171693(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6PBG (X-ray 1.72A ) 6TZT (X-ray 3.06A ) 6U3V (X-ray 2.96A ) |
| DBSNP | rs864309710 rs794727993 rs794727995 rs794727994 rs34997807 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.; [Xenin]: Secreted {ECO:0000250}. |
| Mouse PG classification | NA |
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