Gene Information
Gene NameCOP1
OrganismHomo sapiens (Human)
Gene Length197
Protein NamesCaspase recruitment domain-containing protein 16 (Caspase recruitment domain-only protein 1) (CARD-only protein 1) (Caspase-1 inhibitor COP) (Pseudo interleukin-1 beta converting enzyme) (Pseudo-ICE) (Pseudo-IL1B-converting enzyme)
Target NameNA
Target TypeNA
Gene Age1714 ( ENSG00000143207 )
Evolutionary StageEukaryota
AlphaFoldDBQ5EG05
Gene CardCARD16
Uniprot IDQ5EG05
PfamPF00619
In ASDno
Allosteric Predictionno (-0.028306709)
Ortholog in AnimalsAlpaca_ COP1 ( ortholog_one2one )
Dog_ COP1 ( ortholog_one2one )
GuineaPig_ COP1 ( ortholog_one2one )
Macaque_ COP1 ( ortholog_one2one )
Mouse_ Cop1 ( ortholog_one2one )
Pig_ COP1 ( ortholog_one2one )
Rat_ Cop1 ( ortholog_one2many )
Rabbit_ COP1 ( ortholog_one2one )
OhnologsNA
ParalogsDAW1, WDR43, WDR7, TBL2, POC1B, WDR88, PAFAH1B1, WDR17, NWD1, WDR62, PAK1IP1, DCAF4L1, WDR27, WDR5B, WDR5, NEDD1, MAPKBP1, AHI1, TEP1, SNRNP40, WDR75, WDR81, POC1A, DCAF4L2, DCAF4, WDR38
TissueNA
Tissue SpecificityWidely expressed. Expressed at higher level in placenta, spleen, lymph node and bone marrow. Weakly or not expressed in thymus. {ECO:0000269|PubMed:11432859, ECO:0000269|PubMed:11536016}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs35966314  rs1042744  rs34534919  rs542571 
Subcellular location [CC]NA
Mouse PG classificationNA
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