| Gene Information | |
|---|---|
| Gene Name | COMT |
| Organism | Homo sapiens (Human) |
| Gene Length | 271 |
| Protein Names | Catechol O-methyltransferase (EC 2.1.1.6) |
| Target Name | catechol-o-methyl-transferase |
| Target Type | Successful target |
| Gene Age | 680 ( ENSG00000093010 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P21964 |
| Gene Card | COMT |
| Uniprot ID | P21964 |
| Pfam | PF01596 |
| In ASD | no |
| Allosteric Prediction | yes (0.778369644) |
| Ortholog in Animals | Alpaca_ COMT ( ortholog_one2one ) Dog_ COMT ( ortholog_one2one ) GuineaPig_ COMT ( ortholog_one2one ) Macaque_ COMT ( ortholog_one2one ) Mouse_ Comt ( ortholog_one2one ) Pig_ COMT ( ortholog_one2one ) Rat_ Comt ( ortholog_one2one ) Rabbit_ COMT ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | COMTD1, TOMT |
| Tissue | NA |
| Tissue Specificity | Brain, liver, placenta, lymphocytes and erythrocytes. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3A7E (X-ray 2.80A ) 3BWM (X-ray 1.98A ) 3BWY (X-ray 1.30A ) 4PYI (X-ray 1.35A ) 4PYJ (X-ray 1.90A ) 4PYK (X-ray 2.22A ) 4XUC (X-ray 1.80A ) 4XUD (X-ray 2.40A ) 4XUE (X-ray 2.30A ) 5LSA (X-ray 1.50A ) 6I3C (X-ray 1.34A ) 6I3D (X-ray 1.45A ) |
| DBSNP | rs6270 rs6267 rs5031015 rs4986871 rs4680 |
| Subcellular location [CC] | [Isoform Soluble]: Cytoplasm {ECO:0000269|PubMed:11559542}.; [Isoform Membrane-bound]: Cell membrane {ECO:0000269|PubMed:21846718}; Single-pass type II membrane protein {ECO:0000269|PubMed:21846718}; Extracellular side {ECO:0000269|PubMed:21846718}. |
| Mouse PG classification | LPG |
| click here to return to the previous page | |