| Gene Information | |
|---|---|
| Gene Name | COMP |
| Organism | Homo sapiens (Human) |
| Gene Length | 757 |
| Protein Names | Cartilage oligomeric matrix protein (COMP) (Thrombospondin-5) (TSP5) |
| Target Name | cartilage oligomeric matrix protein |
| Target Type | NA |
| Gene Age | 332 ( ENSG00000105664 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P49747 |
| Gene Card | COMP |
| Uniprot ID | P49747 |
| Pfam | PF11598; PF07645; PF02412; PF05735 |
| In ASD | no |
| Allosteric Prediction | no (-0.594447794) |
| Ortholog in Animals | Alpaca_ COMP ( ortholog_one2one ) Dog_ COMP ( ortholog_one2one ) GuineaPig_ COMP ( ortholog_one2one ) Macaque_ COMP ( ortholog_one2one ) Mouse_ Comp ( ortholog_one2one ) Pig_ COMP ( ortholog_one2one ) Rat_ Comp ( ortholog_one2one ) |
| Ohnologs | THBS4, THBS3 |
| Paralogs | ISM1, THBS3, THBS1, THBS4, THBS2 |
| Tissue | NA |
| Tissue Specificity | Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect. {ECO:0000269|PubMed:16542502, ECO:0000269|PubMed:32686688}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3FBY (X-ray 3.15A ) |
| DBSNP | rs763887855 rs557483957 rs1311845746 rs1568556118 rs137852653 rs137852652 rs137852656 rs1057521130 rs3179763 rs1601054715 rs1601053997 rs28936668 rs137852651 rs137852650 rs28936669 rs193922900 rs1555791425 rs1359984033 rs137852654 rs312262903 rs312262900 rs312262900 rs149551600 rs28936368 rs137852655 rs312262904 rs61752496 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:32686688}. |
| Mouse PG classification | HPG |
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