| Gene Information | |
|---|---|
| Gene Name | SELL |
| Organism | Homo sapiens (Human) |
| Gene Length | 372 |
| Protein Names | L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (TQ1) (gp90-MEL) (CD antigen CD62L) |
| Target Name | l-selectin |
| Target Type | Clinical trial target |
| Gene Age | 382 ( ENSG00000188404 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P14151 |
| Gene Card | SELL |
| Uniprot ID | P14151 |
| Pfam | PF00059; PF00084 |
| In ASD | no |
| Allosteric Prediction | yes (0.005444512) |
| Ortholog in Animals | Alpaca_ SELL ( ortholog_one2one ) Dog_ SELL ( ortholog_one2one ) GuineaPig_ SELL ( ortholog_one2one ) Macaque_ SELL ( ortholog_one2one ) Mouse_ Sell ( ortholog_one2one ) Pig_ SELL ( ortholog_one2one ) Rat_ Sell ( ortholog_one2one ) Rabbit_ SELL ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CR1L, SUSD3, F13B, SELP, SEZ6L2, CFHR2, CFHR1, CSMD1, APOH, SELE, SRPX, SVEP1, SEZ6, C8A, CD55, CSMD2, PAPPA2, SUSD6, C4BPA, C9, CR1, PAPPA, CFB, CD46, C4BPB, CR2, C7, CSMD3, CFHR3, CFH, SEZ6L, CFHR4, CFHR5, SRPX2, C8B, PRF1, SUSD4, C6, C2 |
| Tissue | whole.blood |
| Tissue Specificity | Expressed in B-cell lines and T-lymphocytes. {ECO:0000269|PubMed:2473156}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2LGF (NMR - ) 3CFW (X-ray 2.20A ) 5VC1 (X-ray 1.94A ) |
| DBSNP | rs1131498 rs2229568 rs2229569 rs4987382 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:2509939, ECO:0000269|PubMed:2663882, ECO:0000269|PubMed:28011641}; Single-pass type I membrane protein {ECO:0000305|PubMed:2663882}. |
| Mouse PG classification | NA |
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