| Gene Information | |
|---|---|
| Gene Name | PMS2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 862 |
| Protein Names | Mismatch repair endonuclease PMS2 (EC 3.1.-.-) (DNA mismatch repair protein PMS2) (PMS1 protein homolog 2) |
| Target Name | mismatch repair endonuclease pms2 |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000122512 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P54278 |
| Gene Card | PMS2 |
| Uniprot ID | P54278 |
| Pfam | PF01119; PF08676 |
| In ASD | no |
| Allosteric Prediction | no (-0.12333659) |
| Ortholog in Animals | Alpaca_ PMS2 ( ortholog_one2many ) Dog_ PMS2 ( ortholog_one2one ) GuineaPig_ PMS2 ( ortholog_one2one ) Macaque_ PMS2 ( ortholog_one2one ) Mouse_ Pms2 ( ortholog_one2one ) Pig_ PMS2 ( ortholog_one2one ) Rat_ Pms2 ( ortholog_one2one ) Rabbit_ PMS2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MLH1, MLH3, PMS1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1EA6 (X-ray 2.70A ) 1H7S (X-ray 1.95A ) 1H7U (X-ray 2.70A ) 5U5R (X-ray 2.10A ) 6MFQ (X-ray 2.60A ) 7RCB (X-ray 2.00A ) 7RCI (X-ray 2.12A ) 7RCK (X-ray 2.04A ) |
| DBSNP | rs63750123 rs10254120 rs587781918 rs863224676 rs121434629 rs121434629 rs200313585 rs769554577 rs188006077 rs587779341 rs587779342 rs374704824 rs201811667 rs151251082 rs587779345 rs1805322 rs587779346 rs200513014 rs587778619 rs200726484 rs1805321 rs587781827 rs63750685 rs1805323 rs587779328 rs368516768 rs2228007 rs74902811 rs2228007 rs2228006 rs63750668 rs63750055 rs63750947 rs1805318 rs1805324 rs587779332 rs587781317 rs267608161 rs587779337 rs17420802 rs587780053 rs587781265 rs267608152 rs587780055 rs587779338 rs1060503140 rs267608174 rs371673459 rs1802683 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:23709753, ECO:0000269|PubMed:30653781}. |
| Mouse PG classification | HPG |
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